Dear Editor, We appreciate the comments on our recent review article about strategies to enhance access to diagnosis and treatment for Chagas disease patients [1,2]. We also appreciate the opportunity to respond to them, and expand the discussion on this crucial topic given that it is estimated that no more than 1% of the infected population by Trypanosoma cruzi (of ~7 million people) ultimately get access to treatment [3]. The letter comments mainly refer to two of the sections of the review article: diagnostics to detect the infection (section 2), and treatment opportunities and possibilities (section 7).