Concentration and avidity of antibodies to different
                circumsporozoite epitopes correlate with RTS,S/AS01E malaria
                vaccine efficacy

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RECERCAT Home > Universitat de Barcelona > ISGlobal - Institut de Salut Global de Barcelona > Articles publicats en revistes (ISGlobal) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/134962

dc.contributor.author	Dobaño, Carlota, 1969-
dc.contributor.author	Sanz, Héctor
dc.contributor.author	Sorgho, Hermann
dc.contributor.author	Dosoo, David
dc.contributor.author	Mpina, Maximilian
dc.contributor.author	Ubillos, Itziar
dc.contributor.author	Aguilar, Ruth
dc.contributor.author	Ford, Tom
dc.contributor.author	Díez-Padrisa, Núria
dc.contributor.author	Williams, Nana A.
dc.contributor.author	Ayestaran, Aintzane
dc.contributor.author	Traore, Ousmane
dc.contributor.author	Nhabomba, Augusto J.
dc.contributor.author	Jairoce, Chenjerai
dc.contributor.author	Waitumbi, John
dc.contributor.author	Agnandji, Selidji Todagbe
dc.contributor.author	Kariuki, Simon
dc.contributor.author	Abdulla, Salim
dc.contributor.author	Aponte, John J.
dc.contributor.author	Mordmüller, Benjamin
dc.contributor.author	Asante, Kwaku Poku
dc.contributor.author	Owusu-Agyei, Seth
dc.contributor.author	Tinto, Halidou
dc.contributor.author	Campo, Joseph J.
dc.contributor.author	Moncunill, Gemma
dc.contributor.author	Gyan, Ben
dc.contributor.author	Valim, Clarissa
dc.contributor.author	Daubenberger, Claudia
dc.date	2019-06-12T14:27:01Z
dc.date	2019-06-12T14:27:01Z
dc.date	2019-05-15
dc.date	2019-05-27T09:03:42Z
dc.identifier.citation	2041-1723
dc.identifier.uri	http://hdl.handle.net/2445/134962
dc.format	13 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Nature Publishing Group
dc.relation	Reproducció del document publicat a: http://dx.doi.org/10.1038/s41467-019-10195-z
dc.relation	Nature Communications, 2019, vol. 10
dc.relation	http://dx.doi.org/10.1038/s41467-019-10195-z
dc.rights	cc by (c) Dobaño et al., 2019
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by/3.0/es/
dc.subject	Vacuna de la malària
dc.subject	Infants
dc.subject	Africans
dc.subject	Malaria vaccine
dc.subject	Children
dc.title	Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	RTS,S/AS01E has been tested in a phase 3 malaria vaccine study with partial efficacy in African children and infants. In a cohort of 1028 subjects from one low (Bagomoyo) and two high (Nanoro, Kintampo) malaria transmission sites, we analysed IgG plasma/serum concentration and avidity to CSP (NANP-repeat and C-terminal domains) after a 3-dose vaccination against time to clinical malaria events during 12-months. Here we report that RTS,S/AS01E induces substantial increases in IgG levels from pre- to post-vaccination (p\xE2\x80\x89<\xE2\x80\x890.001), higher in NANP than C-terminus (2855 vs 1297 proportional change between means), and higher concentrations and avidities in children than infants (p\xE2\x80\x89<\xE2\x80\x890.001). Baseline CSP IgG levels are elevated in malaria cases than controls (p\xE2\x80\x89<\xE2\x80\x890.001). Both, IgG magnitude to NANP (hazard ratio [95% confidence interval] 0.61 [0.48-0.76]) and avidity to C-terminus (0.07 [0.05-0.90]) post-vaccination are significantly associated with vaccine efficacy. IgG avidity to the C-terminus emerges as a significant contributor to RTS,S/AS01E-mediated protection.

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