Title:
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Cell Migration Driven by Cooperative Substrate Deformation Patterns
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Author:
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Angelini, Thomas E.; Hannezo, Edouard; Trepat Guixer, Xavier; Fredberg, Jeffrey J.; Weitz, David A.
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Other authors:
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Universitat de Barcelona |
Abstract:
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Most eukaryotic cells sense and respond to the mechanical properties of their surroundings. This can strongly influence their collective behavior in embryonic development, tissue function, and wound healing. We use a deformable substrate to measure collective behavior in cell motion due to substrate mediated cell-cell interactions. We quantify spatial and temporal correlations in migration velocity and substrate deformation, and show that cooperative cell-driven patterns of substrate deformation mediate long-distance mechanical coupling between cells and control collective cell migration. |
Subject(s):
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-Cèl·lules eucariotes -Migració cel·lular -Eukaryotic cells -Cell migration |
Rights:
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(c) American Physical Society, 2010
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Document type:
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Article Article - Published version |
Published by:
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American Physical Society
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