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Título:
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A randomised study on the clinical progress of high-risk elective major gastrointestinal surgery patients treated with olive oil-based parenteral nutrition with or without a fish oil supplement
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Autor/a:
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Badia Tahull, Maria Bella; Llop Talaverón, Josep Manuel; Leiva Badosa, Elisabet; Biondo, Sebastián; Farrán Teixidor, Leandre; Ramon Torrell, Josep M. (Josep Maria); Jódar Masanés, Ramón José
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Abstract:
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n-3 Fatty acids have clinical benefits. The primary aim of the present study was the assessment of infection in patients who underwent major high-risk elective gastrointestinal surgery receiving postoperatively fish oil (FO)-supplemented parenteral nutrition (PN), compared with those receiving a standard olive oil (OO) emulsion. The secondary aims were the assessment of anti-inflammatory response and evaluation of tolerance and safety of these emulsions. A prospective, randomised, double-blind study was performed in patients requiring at least 5 d of PN. An isoenergetic and isoproteic formula was administered: group A received OO alone, while group B received OO that was partially replaced with FO (16.6 %, w/w). End points were outcome measures (mortality, sepsis, infection, hospitalisation days and PN duration), inflammatory response (C-reactive protein (CRP), prealbumin and leucocytes) and safety (TAG and glucose metabolism, and liver and kidney function). Statistical analysis was done using Student's t test and Fisher's exact test (P < 0.05). Twenty-seven patients were evaluated, with thirteen patients receiving FO. In this group, a significantly lower incidence of infections was found (23.1 v. 78.6 %, P = 0.007). CRP, prealbumin and leucocytes were not significantly different between the groups. There were no differences in safety parameters. We conclude that high-risk surgical patients receiving FO-supplemented PN for 5 d present a lower incidence of infection. Emulsions were safe and well tolerated. |
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Materia(s):
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-Agents antiinfecciosos
-Cirurgia
-Malalties del tracte gastrointestinal
-Alimentació parenteral
-Ús terapèutic
-Emulsions
-Olis de peix
-Cura postoperatòria
-Programes de prevenció
-Anti-infective agents
-Surgery
-Gastrointestinal system diseases
-Parenteral feeding
-Therapeutic use
-Emulsions
-Fish oils
-Postoperative care
-Prevention programs |
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Derechos:
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(c) Cambridge University Press, 2010
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Tipo de documento:
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Artículo
Artículo - Versión publicada |
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Editor:
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Cambridge University Press
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Compartir:
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