Title:
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Cooperative force generation of KIF1A Brownian motors
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Author:
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Oriola Santandreu, David; Casademunt i Viader, Jaume
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Other authors:
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Universitat de Barcelona |
Abstract:
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KIF1A is a kinesin motor protein that can work processively in a monomeric (single-headed) form by using a noise-driven ratchet mechanism. Here, we show that the combination of a passive diffusive state and finite-time kinetics of adenosine triphosphate hydrolysis provides a powerful mechanism of cooperative force generation, implying for instance that ∼ 10 monomeric KIF1As can team up to become ∼ 100 times stronger than a single one. Consequently, we propose that KIF1A could outperform conventional (double-headed) kinesin collectively and thus explain its specificity in axonal trafficking. We elucidate the cooperativity mechanism with a lattice model that includes multiparticle transitions. |
Subject(s):
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-Proteïnes quinases -Monòmers -Protein kinases -Monomers |
Rights:
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(c) American Physical Society, 2013
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Document type:
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Article Article - Published version |
Published by:
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American Physical Society
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