Title:
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Translation of neutrally evolving peptides provides a basis for de novo gene evolution
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Author:
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Ruiz Orera, Jorge; Verdaguer Grau, Pol; Villanueva Cañas, José Luis; Messeguer Peypoch, Xavier; Albà Soler, M. Mar
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Other authors:
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Universitat Politècnica de Catalunya. Departament de Ciències de la Computació; Universitat Politècnica de Catalunya. ALBCOM - Algorismia, Bioinformàtica, Complexitat i Mètodes Formals |
Abstract:
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Accumulating evidence indicates that some protein-coding genes have originated de novo from previously non-coding genomic sequences. However, the processes underlying de novo gene birth are still enigmatic. In particular, the appearance of a new functional protein seems highly improbable unless there is already a pool of neutrally evolving peptides that are translated at significant levels and that can at some point acquire new functions. Here, we use deep ribosome-profiling sequencing data, together with proteomics and single nucleotide polymorphism information, to search for these peptides. We find hundreds of open reading frames that are translated and that show no evolutionary conservation or selective constraints. These data suggest that the translation of these neutrally evolving peptides may be facilitated by the chance occurrence of open reading frames with a favourable codon composition. We conclude that the pervasive translation of the transcriptome provides plenty of material for the evolution of new functional proteins. |
Abstract:
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Peer Reviewed |
Subject(s):
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-Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica -Protein research -Peptides -Ribosome profiling -Translation -De novo gene -Long non-coding RNA -Polymorphism -Natural selection -Proteïnes -- Investigació -Pèptids |
Rights:
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Document type:
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Article - Submitted version Article |
Published by:
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Springer
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