The effect of hygroscopicity on flowability of powders and bulk solids with applications in the packaging industry is experimentally and numerically investigated. Firstly, four granular materials are tested at different water contents to study the impact of relative humidity on some hydro-mechanical properties, namely the hydraulic diffusivity on wetting, as well as the shear strength and compressibility properties of the materials. Next, a capillary model covering a wider water content range –compared to the previous tests– is applied to discrete element simulations of a granular column collapse set-up. These simulations give further insight into important aspects of grain hygroscopicity in packaging and other industrial applications (such as the kinematics of flow and flowability issues), which are outside the scope of conventional experimental testing.