dc.contributor |
Universitat de Barcelona |
dc.contributor.author |
Prats, C. |
dc.contributor.author |
Arias Sampériz, Bárbara |
dc.contributor.author |
Ortet, G. |
dc.contributor.author |
Ibáñez, M.I. |
dc.contributor.author |
Moya, J. |
dc.contributor.author |
Pomarol-Clotet, Edith |
dc.contributor.author |
Fañanás Saura, Lourdes |
dc.contributor.author |
Fatjó-Vilas Mestre, Mar |
dc.date |
2019-01-31T15:41:39Z |
dc.date |
2019-01-31T15:41:39Z |
dc.date |
2017-03-15 |
dc.date |
2019-01-31T15:41:39Z |
dc.identifier.citation |
0165-0327 |
dc.identifier.citation |
668811 |
dc.identifier.uri |
http://hdl.handle.net/2445/127787 |
dc.format |
7 p. |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Elsevier B.V. |
dc.relation |
Versió postprint del document publicat a: https://doi.org/10.1016/j.jad.2016.11.017 |
dc.relation |
Journal of Affective Disorders, 2017, vol. 211, p. 92-98 |
dc.relation |
https://doi.org/10.1016/j.jad.2016.11.017 |
dc.rights |
cc-by-nc-nd (c) Elsevier B.V., 2017 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
http://creativecommons.org/licenses/by-nc-nd/3.0/es |
dc.subject |
Proteïnes |
dc.subject |
Malalties mentals |
dc.subject |
Neurones |
dc.subject |
Proteins |
dc.subject |
Mental illness |
dc.subject |
Neurons |
dc.title |
Neurotrophins role in depressive symptoms and executive function performance: Association analysis of NRN1 gene and its interaction with BDNF gene in a non-clinical sample. |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/acceptedVersion |
dc.description.abstract |
BACKGROUND: Neuritin-1 is a neurotrophic factor involved in synaptic plasticity that has been associated with depressive disorders, schizophrenia and cognitive performance. The study of genotype-phenotype relationships in healthy individuals is a useful framework to investigate the etiology of brain dysfunctions. We therefore aimed to investigate in a non-clinical sample whether NRN1 gene contributes to the psychopathological profile, with a particular focus on the clinical dimensions previously related to the NRN1 gene (i.e. depressive and psychotic). Furthermore, we aimed to analyze: i) the role of NRN1 on executive functions, ii) whether the association between either NRN1-psychopathological profile or NRN1-cognitive performance is moderated by the BDNF gene. METHODS: The sample comprised 410 non-clinical subjects who filled in the self-reported Brief Symptom Inventory (BSI) and were assessed for executive performance (Verbal Fluency, Wisconsin Card Sorting Test (WCST) and Letter-Number subscale (WAIS-III)). Genotyping included nine SNPs in NRN1 and one in BDNF. RESULTS: i) GG homozygotes (rs1475157-NRN1) showed higher scores on BSI depressive dimension and on total scores compared to A carriers (corrected p-values: 0.0004 and 0.0003, respectively). ii) a linear trend was detected between GG genotype of rs1475157 and a worse cognitive performance in WCST total correct responses (uncorrected p-value: 0.029). iii) Interaction between rs1475157-NRN1 and Val66Met-BDNF was found to modulate depressive symptoms (p=0.001, significant after correction). LIMITATIONS: Moderate sample size; replication in a larger sample is needed. CONCLUSIONS: NRN1 is associated with depressive symptoms and executive function in a non-clinical sample. Our results also suggest that the role of NRN1 seems to be modulated by BDNF. |