Seismic isolation systems are essentially designed to preserve structural safety, prevent occupants injury and properties damage. An active saturated LMI-based control design is proposed to attenuate seismic disturbances in base-isolated structures under saturation actuators. Using a mathematical model of an eight-storied building structure, an active control algorithm is designed. Performance evaluation of the controller is carried out in a simplified model version of a benchmark building system, which is recognized as a state-of-the-art model for numerical experiments of structures under seismic perturbations. Experimental results show that the proposed algorithm is robust with respect to model and seismic perturbations. Finally, the performance indices show that the proposed controller behaves satisfactorily and with a reasonable control effort.