dc.contributor |
Universitat de Barcelona |
dc.contributor.author |
García Layana, Alfredo |
dc.contributor.author |
Ciufo, Gianfranco |
dc.contributor.author |
Toledo, Estefanía |
dc.contributor.author |
Martínez-González, Miguel Ángel, 1957- |
dc.contributor.author |
Corella Piquer, Dolores |
dc.contributor.author |
Fitó Colomer, Montserrat |
dc.contributor.author |
Estruch Riba, Ramon |
dc.contributor.author |
Gómez Gracia, Enrique |
dc.contributor.author |
Fiol Sala, Miguel |
dc.contributor.author |
Lapetra, José |
dc.contributor.author |
Serra Majem, Lluís |
dc.contributor.author |
Pintó Sala, Xavier |
dc.contributor.author |
Portillo, María P. |
dc.contributor.author |
Sorlí, José V. |
dc.contributor.author |
Bulló, Mònica |
dc.contributor.author |
Vinyoles, Ernest |
dc.contributor.author |
Sala Vila, Aleix |
dc.contributor.author |
Ros Rahola, Emilio |
dc.contributor.author |
Salas Salvadó, Jordi |
dc.contributor.author |
Arós, Fernando |
dc.date |
2019-01-02T15:41:22Z |
dc.date |
2019-01-02T15:41:22Z |
dc.date |
2017-05-03 |
dc.date |
2019-01-02T15:41:22Z |
dc.identifier.citation |
2072-6643 |
dc.identifier.citation |
677056 |
dc.identifier.uri |
http://hdl.handle.net/2445/127103 |
dc.format |
12 p. |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
MDPI |
dc.relation |
Reproducció del document publicat a: https://doi.org/10.3390/nu9050453 |
dc.relation |
Nutrients, 2017, vol. 9, num. 5 |
dc.relation |
https://doi.org/10.3390/nu9050453 |
dc.rights |
cc-by (c) García Layana, Alfredo et al., 2017 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
http://creativecommons.org/licenses/by/3.0/es |
dc.subject |
Cuina mediterrània |
dc.subject |
Cirurgia de cataractes |
dc.subject |
Antioxidants |
dc.subject |
Cataractes |
dc.subject |
Mediterranean cooking |
dc.subject |
Cataract surgery |
dc.subject |
Antioxidants |
dc.subject |
Cataract |
dc.title |
The effect of a mediterranean diet on the incidence of cataract surgery |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.description.abstract |
Background: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce oxidative stress, has been suggested as a means to decrease the risk of developing cataract. We aimed to investigate the hypothesis that an intervention with a Mediterranean diet (MedDiet) rather than a low-fat diet could decrease the incidence of cataract surgery in elderly subjects. Methods: We included 5802 men and women (age range: 55-80 years) from the Prevencion con Dieta Mediterronea study (multicenter, parallel-group, randomized controlled clinical trial) who had not undergone cataract surgery. They were randomly assigned to one of three intervention groups: (1) a MedDiet enriched with extra-virgin olive oil (EVOO) (n = 1998); (2) a MedDiet enriched with nuts (n = 1914), and a control group recommended to follow a low-fat diet (n = 1890). The incidence of cataract surgery was recorded yearly during follow-up clinical evaluations. Primary analyses were performed on an intention-to-treat basis. Cox regression analyses were used to assess the relationship between the nutritional intervention and the incidence of cataract surgery. Results: During a follow-up period of 7.0 years (mean follow-up period: 5.7 years; median: 5.9 years), 559 subjects underwent cataract surgery. Two hundred and six participants from the MedDiet + EVOO group, 174 from the MedDiet + Nuts group, and 179 from the control group underwent cataract surgery. We did not observe a reduction in the incidence of cataract surgery in the MedDiet groups compared to the control group. The multivariable adjusted hazard ratios were 1.03 (95% confidence interval [CI]: 0.84-1.26, p = 0.79) for the control group versus the MedDiet + EVOO group and 1.06 (95% CI: 0.86-1.31, p = 0.58) for the control group versus the MedDiet + Nuts group. Conclusions: To our knowledge, this is the first large randomized trial assessing the role of a MedDiet on the incidence of cataract surgery. Our results showed that the incidence of cataract surgery was similar in the MedDiet with EVOO, MedDiet with nuts, and low-fat diet groups. Further studies are necessary to investigate whether a MedDiet could have a preventive role in cataract surgery. |