Título:
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Toward angiogenesis inhibitors based on the conjugation of organometallic platinum(II) complexes to RGD peptides
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Autor/a:
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Zamora, Ana; Gandioso, Albert; Massaguer i Vall-llovera, Anna; Buenestado, Silvia; Calvis, Carme; Hernández, José Luis; Mitjans, Francesc; Rodríguez, Venancio; Ruiz, José; Marchán Sancho, Vicente
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Otros autores:
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Universitat de Barcelona |
Abstract:
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A novel conjugate between a cyclometalated platinum(II) complex with dual antiangiogenic and antitumor activity and a cyclic peptide containing the RGD sequence (-Arg-Gly-Asp-) has been synthesized by combining solid- and solution-phase methodologies. Although peptide conjugation rendered a non-cytotoxic compound in all tested tumor cell lines (± αV β3 and αV β5 integrin receptors), the antiangiogenic activity of the Pt-c(RGDfK) conjugate in human umbilical vein endothelial cells at sub-cytotoxic concentrations opens the way to the design of a novel class of angiogenesis inhibitors through conjugation of metallodrugs with high antiangiogenic activity to cyclic RGD-containing peptides or peptidomimetic analogues. |
Materia(s):
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-Angiogènesi -Càncer -Pèptids -Compostos organometàl·lics -Neovascularization -Cancer -Peptides -Organometallic compounds |
Derechos:
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(c) Wiley-VCH, 2018
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Tipo de documento:
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Artículo Artículo - Versión aceptada |
Editor:
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Wiley-VCH
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Compartir:
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