dc.contributor.author |
Varani, Andrés P. |
dc.contributor.author |
Aso Pérez, Ester |
dc.contributor.author |
Maldonado, Rafael, 1961- |
dc.contributor.author |
Balerio, Graciela N. |
dc.date |
2014 |
dc.identifier.citation |
Varani AP, Aso E, Maldonado R, Balerio GN. Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine. Eur J Pharmacol. 2014 Sep 5; 738: 200-5. DOI: 10.1016/j.ejphar.2014.05.039 |
dc.identifier.citation |
0014-2999 |
dc.identifier.citation |
http://dx.doi.org/10.1016/j.ejphar.2014.05.039 |
dc.identifier.uri |
http://hdl.handle.net/10230/23334 |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Elsevier |
dc.relation |
info:eu-repo/grantAgreement/ES/3PN/SAF2011-29864 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
© Elsevier http://dx.doi.org/10.1016/j.ejphar.2014.05.039 |
dc.subject |
Nicotina |
dc.subject |
Ratolins |
dc.title |
Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/acceptedVersion |
dc.description.abstract |
The aim of the present study was to evaluate the possible involvement of GABAB receptors in nicotine-induced hypolocomotion and antinociceptive effects in mice. Animals were exposed to nicotine only once. Acute nicotine hydrogen tartrate salt (3mg/kg; subcutaneous, s.c.) administration induced hypolocomotion and antinociceptive responses in the tail-immersion and the hot-plate tests. The effects of pretreatment with either the GABAB receptor agonist baclofen (1, 2 and 3mg/kg; intraperitoneal, i.p.) or GABAB receptor antagonist 2-hydroxysaclofen (0.25, 0.5 and 1mg/kg; i.p.) were evaluated on these behavioral nicotine responses. The GABAB receptor agonist, baclofen (3mg/kg, i.p.) abolished nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, but did not modify nicotine-induced hypolocomotion. In addition, the GABAB receptor antagonist, 2-hydroxysaclofen (1mg/kg, i.p.) increased nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, and abolished nicotine-induced hypolocomotion. The present results shed light that the GABAB receptor has an important role in mediating specific acute nicotine responses such as hypolocomotion and antinociception in mice. |
dc.description.abstract |
This work has been supported by grants from University of Buenos Aires (UBACyT B016 and UBACyT 2013–2016 No. 20020120100244), CONICET (PIP 11420090100303), Spanish “Ministerio de Ciencia e Innovación” (#SAF2011-29864), “Instituto de Salud Carlos III” (RETICS: #RD06/0001/0001, #RD06/0001/1004), Plan Nacional sobre Drogas (PNSD #2009/026), the Catalan Government (SGR2009-00131) and the ICREA Foundation (ICREA Academia-2008) |