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Título:	Hydraulic fracturing in cells and tissues: fracking meets cell biology
Autor/a:	Arroyo Balaguer, Marino; Trepat, Xavier
Otros autores:	Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental; Universitat Politècnica de Catalunya. LACÀN - Mètodes Numèrics en Ciències Aplicades i Enginyeria
Abstract:	The animal body is largely made of water. A small fraction of body water is freely flowing in blood and lymph, but most of it is trapped in hydrogels such as the extracellular matrix (ECM), the cytoskeleton, and chromatin. Besides providing a medium for biological molecules to diffuse, water trapped in hydrogels plays a fundamental mechanical role. This role is well captured by the theory of poroelasticity, which explains how any deformation applied to a hydrogel causes pressure gradients and water flows, much like compressing a sponge squeezes water out of it. Here we review recent evidence that poroelastic pressures and flows can fracture essential biological barriers such as the nuclear envelope, the cellular cortex, and epithelial layers. This type of fracture is known in engineering literature as hydraulic fracturing or ‘fracking’. © 2016 Elsevier Ltd. All rights reserved.
Abstract:	Peer Reviewed
Materia(s):	-Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Anatomia i fisiologia humana -Àrees temàtiques de la UPC::Enginyeria dels materials::Assaig de materials::Assaig de fractura -Cell Biology -Hydraulic fracturing -Biologia cel·lular -Fracturació hidràulica
Derechos:	Attribution-NonCommercial-NoDerivs 3.0 Spain http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Tipo de documento:	Artículo - Versión presentada Artículo
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