dc.contributor |
Universitat de Barcelona |
dc.contributor.author |
Miranda i Rius, Jaume |
dc.contributor.author |
Brunet i Llobet, Lluís |
dc.contributor.author |
Lahor i Soler, Eduard |
dc.contributor.author |
Dios-Miranda, David de |
dc.contributor.author |
Giménez Rubio, Josep Anton |
dc.date |
2018-03-21T08:53:54Z |
dc.date |
2018-03-21T08:53:54Z |
dc.date |
2017-05-10 |
dc.date |
2018-03-21T08:53:54Z |
dc.identifier.citation |
1746-160X |
dc.identifier.citation |
671503 |
dc.identifier.uri |
http://hdl.handle.net/2445/120942 |
dc.format |
7 p. |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
BioMed Central |
dc.relation |
Reproducció del document publicat a: https://doi.org/10.1186/s13005-017-0140-6 |
dc.relation |
Head & Face Medicine, 2017, vol. 13, num. 7 |
dc.relation |
https://doi.org/10.1186/s13005-017-0140-6 |
dc.rights |
cc-by (c) Miranda i Rius, Jaume et al., 2017 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
http://creativecommons.org/licenses/by/3.0/es |
dc.subject |
Maloclusió |
dc.subject |
Apnea |
dc.subject |
Trastorns del creixement |
dc.subject |
Inflamació |
dc.subject |
Malocclusion |
dc.subject |
Apnea |
dc.subject |
Growth disorders |
dc.subject |
Inflammation |
dc.title |
GH-secreting pituitary macroadenoma (acromegaly) associated with progressive dental malocclusion and refractory CPAP treatment |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.description.abstract |
Background: A link between progressive dental malocclusion, the use of a continuous positive airway pressure mask and GH-secreting pituitary macroadenoma (acromegaly) has not been previously reported. The present clinicopathological analysis stresses that tooth malposition should not be seen exclusively as a local process. Case Presentation: A 62-year-old caucasian man with no relevant medical history reported difficulty chewing food and perceived voice alteration during his annual periodontal check-up. He also referred stiffness of the tongue, face, and submandibular area. The patient had been diagnosed with obstructive sleep apnea syndrome two years previously, since when he had worn a continuous positive airway pressure device during sleep. Exploration of the occlusion revealed significant changes: an atypical left lateral and anterior open bite with major buccoversion of teeth 33, 34, 35, 36. Inspection of the soft tissue revealed only macroglossia, although external palpation indicated a subcutaneous stiffness of the submandibular area. General analytical tests, including hormone profiles, and magnetic resonance imaging confirmed the diagnosis of acromegaly induced by a pituitary adenoma. Intrasellar tumor resection via transsphenoidal approach was performed. After surgery, the patient already noted a marked improvement of all symptoms associated with the acromegaly. Desaturation data also evolved favourably and the pulmonologist advised the patient to abandon the continuous positive airway pressure treatment. Conclusion: Progressive dental malocclusion may be associated with a systemic disease and the use of a nasal mask with premaxillary support may distort the diagnosis of acromegaly. |