Modification of titanium surfaces by adding antibiotic-loaded PHB spheres and PEG for biomedical applications

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dc.contributor	Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria
dc.contributor	Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.contributor	Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.contributor.author	Rodriguez Contreras, Alejandra
dc.contributor.author	Marqués Calvo, M. Soledad
dc.contributor.author	Gil Mur, Francisco Javier
dc.contributor.author	Manero Planella, José María
dc.date	2016-08-01
dc.identifier.citation	Rodriguez , A., Marques, M.S., Gil, J., Manero, J. Modification of titanium surfaces by adding antibiotic-loaded PHB spheres and PEG for biomedical applications. "Journal of materials science. Materials in medicine", 1 Agost 2016, vol. 27, núm. 8.
dc.identifier.citation	0957-4530
dc.identifier.citation	10.1007/s10856-016-5723-4
dc.identifier.uri	http://hdl.handle.net/2117/90018
dc.language.iso	eng
dc.relation	info:eu-repo/grantAgreement/ES/6PN/MAT2012-30706
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Cirurgia
dc.subject	Titanium
dc.subject	Nanoparticles
dc.subject	Metals--Heat treatment
dc.subject	Surgery--Complications
dc.subject	Implants, Artificial
dc.subject	HEAT-TREATMENTS
dc.subject	TI
dc.subject	NANOPARTICLES
dc.subject	POLY(3-HYDROXYBUTYRATE-CO-3-HYDROXYHEXANOATE)
dc.subject	3-AMINOPROPYLTRIETHOXYSILANE
dc.subject	INFECTIONS
dc.subject	ADHESION
dc.subject	ACID
dc.subject	Titani
dc.subject	Nanopartícules
dc.subject	Metalls -- Tractament tèrmic
dc.subject	Implants artificials
dc.subject	Cirurgia -- Complicacions
dc.title	Modification of titanium surfaces by adding antibiotic-loaded PHB spheres and PEG for biomedical applications
dc.type	info:eu-repo/semantics/submittedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	Novel researches are focused on the prevention and management of post-operative infections. To avoid this common complication of implant surgery, it is preferable to use new biomaterials with antibacterial properties. Therefore, the aim of this work is to develop a method of combining the antibacterial properties of antibiotic-loaded poly(3-hydroxybutyrate) (PHB) nano-and micro-spheres and poly(ethylene glycol) (PEG) as an antifouling agent, with titanium (Ti), as the base material for implants, in order to obtain surfaces with antibacterial activity. The Ti surfaces were linked to both PHB particles and PEG by a covalent bond. This attachment was carried out by firstly activating the surfaces with either Oxygen plasma or Sodium hydroxide. Further functionalization of the activated surfaces with different alkoxysilanes allows the reaction with PHB particles and PEG. The study confirms that the Ti surfaces achieved the antibacterial properties by combining the antibiotic-loaded PHB spheres, and PEG as an antifouling agent.

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