dc.contributor |
Universitat de Barcelona |
dc.contributor.author |
Podzamczer Palter, Daniel |
dc.contributor.author |
Rojas, Jhon Fredy |
dc.contributor.author |
Neves, Isabel |
dc.contributor.author |
Ferrer, Elena |
dc.contributor.author |
Llibre, Josep M. |
dc.contributor.author |
Leal, Manuel |
dc.contributor.author |
Gorgolas, Miguel |
dc.contributor.author |
Jose, Crusells Mª |
dc.contributor.author |
Gatell, José M. |
dc.contributor.author |
Abreu, Correia |
dc.contributor.author |
Curto, J. J. (Jorge Juan) |
dc.contributor.author |
Domingo, Pere (Domingo Pedrol) |
dc.contributor.author |
Barrufet, Pilar M. |
dc.contributor.author |
Rozas, Nerea |
dc.date |
2017-11-03T11:34:43Z |
dc.date |
2017-11-03T11:34:43Z |
dc.date |
2014-11-02 |
dc.date |
2017-11-03T11:34:43Z |
dc.identifier.citation |
1758-2652 |
dc.identifier.citation |
649147 |
dc.identifier.uri |
http://hdl.handle.net/2445/117371 |
dc.format |
1 p. |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
BioMed Central |
dc.relation |
Reproducció del document publicat a: http://doi.org/10.7448/IAS.17.4.19773 |
dc.relation |
Journal of the International AIDS Society, 2014, vol. 17, num. 4 Suppl 3, p. 19773 |
dc.relation |
http://doi.org/10.7448/IAS.17.4.19773 |
dc.rights |
cc-by (c) Podzamczer, Daniel et al., 2014 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
http://creativecommons.org/licenses/by/3.0/es |
dc.subject |
VIH (Virus) |
dc.subject |
Antiretrovirals |
dc.subject |
Toxicitat dels medicaments |
dc.subject |
Estudi de casos |
dc.subject |
HIV (Viruses) |
dc.subject |
Antiretroviral agents |
dc.subject |
Drug toxicity |
dc.subject |
Case studies |
dc.title |
Effectiveness and tolerability of abacavir-lamivudine-nevirapine (ABC/3TC/NVP) in a multicentre cohort of HIV-infected, ARV-naïve patients |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.description.abstract |
PURPOSE: Very scarce information has been published to date with the combination of ABC/3TC/NVP but it is currently being used in clinical practice in Spain and Portugal. Our aim was to present the clinical experience with this regimen in a cohort of adult HIV-infected antiretroviral (ARV)-naïve patients. METHODS: Retrospective, multicentre, cohort study. Consecutive adult HIV-infected ARV-naïve HLA-B*5701-negative patients, who started ABC/3TC/NVP between 2005-2013, with at least one follow-up visit, were included. Demographic, clinical and laboratory variables were assessed at baseline, month 1, and every three-four months thereafter. The primary end point was HIV-1 viral load (VL)<40 c/mL at 48 weeks. Data were analyzed by intent-to-treat (ITT) (switch=failure, and missing=failure) and on treatment (OT) analyses. RESULTS: 78 patients were included. Median follow up was 26 (0.1-84) months. 86% were male, median age 41 (23-69) years, 9% had AIDS, 8% were HCV+, baseline CD4 was 275 (10-724) cells/µL and median VL 4.58 (3.02-6.92) log. After 48 weeks, VL was<40 c/mL in 89.8% (OT), 79.7% (M=F) and 65.4% (S=F) and at 96 weeks in 88.5%, 78.9% and 61.6%, respectively. CD4 increased +246 (p<0.001) and +292 (p<0.001) cells/uL after 48 and 96 weeks, respectively. One or more drugs of the regimen were discontinued in 33 (42.3%) patients. In 15 (19.2%) patients (13 NVP, 2 ABC/3TC) therapy was stopped due to toxicity after a median of one month (in only two cases after six months of follow up): 80% of them had rash/liver toxicity. Six (7.7%) patients discontinued ART due to virologic failure, five (6.4%) because of other reasons and seven (9%) were lost to follow-up. ALT but not AST significantly increased (+0.07 ukat/L at 96 weeks, p=0.033). A significant increase of 25%, 26% and 42% in total cholesterol, LDLc and HDLc, respectively, and a significant decrease in TC/HDL ratio (6%, p=0.008) was observed after 96 weeks. CONCLUSIONS: Despite a considerable proportion of patients had to stop therapy due to toxicity (most associated with NVP), those initially tolerating this regimen presented a high virologic and immunologic response after 96 weeks, as well as a favourable lipid profile. ABC/3TC/NVP may be a suitable alternative first regimen, mainly in countries with economic constraints. |