Voltammetric determination of antihypertensive drug hydrochlorothiazide using screen-printed electrodes modified with L- glutamic acid

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dc.contributor	Universitat de Barcelona
dc.contributor.author	González-Vargas, Camilo
dc.contributor.author	Serrano i Plana, Núria
dc.contributor.author	Ariño Blasco, Cristina
dc.contributor.author	Salazar, Ricardo
dc.contributor.author	Esteban i Cortada, Miquel
dc.contributor.author	Díaz Cruz, José ManuelM.
dc.date	2017-10-02T07:24:34Z
dc.date	2017-10-02T07:24:34Z
dc.date	2017-09-17
dc.date	2017-10-02T07:24:34Z
dc.identifier.citation	2227-9040
dc.identifier.citation	673372
dc.identifier.uri	http://hdl.handle.net/2445/116084
dc.format	12 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	MDPI
dc.relation	Reproducció del document publicat a: https://doi.org/10.3390/chemosensors5030025
dc.relation	Chemosensors, 2017, vol. 5, num. 25, p. 1-12
dc.relation	https://doi.org/10.3390/chemosensors5030025
dc.rights	cc-by (c) González-Vargas, Camilo et al., 2017
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.subject	Anàlisi electroquímica
dc.subject	Voltametria
dc.subject	Electrochemical analysis
dc.subject	Voltammetry
dc.title	Voltammetric determination of antihypertensive drug hydrochlorothiazide using screen-printed electrodes modified with L- glutamic acid
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	This work deals with the development of screen-printed carbon electrodes modified with L-glutamic acid via two different approaches: electropolymerization (SPCE/PGA) and aryl diazonium electrochemical grafting (SPCE/EGA). SPCE/PGA and SPCE/EGA were analytically compared in the determination of hydrochlorothiazide (HCTZ) by differential pulse voltammetry. Both electrochemical characterization and analytical performance indicate that SPCE/EGA is a much better sensor for HCTZ. The detection and quantification limits were at the level of micromol L-1 with a very good linearity in the studied concentration range. In addition, the proposed SPCE/EGA was successfully applied for the determination of HCTZ in an anti-hypertensive drug with high reproducibility and good trueness.

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