Monitoring treatment of field cancerisation with 3% diclofenac sodium 2.5% hyaluronic acid by reflectance confocal microscopy: a histologic correlation

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dc.contributor	Universitat de Barcelona
dc.contributor.author	Malvehy, J. (Josep)
dc.contributor.author	Roldán-Marín, Rodrigo
dc.contributor.author	Iglesias-García, Pablo
dc.contributor.author	Díaz Lorca, Maria Alba
dc.contributor.author	Puig i Sardà, Susana
dc.date	2017-04-19T11:07:28Z
dc.date	2017-04-19T11:07:28Z
dc.date	2014-04-03
dc.date	2017-04-19T11:07:28Z
dc.identifier.citation	0001-5555
dc.identifier.citation	642109
dc.identifier.uri	http://hdl.handle.net/2445/109784
dc.format	6 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Society for the Publication of Acta Dermato-Venereologica
dc.relation	Reproducció del document publicat a: https://doi.org/10.2340/00015555-1860
dc.relation	Acta Dermato-Venereologica, 2014, vol. 95, num. 1, p. 45-50
dc.relation	https://doi.org/10.2340/00015555-1860
dc.rights	(c) Malvehy, J. (Josep) et al., 2014
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Malalties de la pell
dc.subject	Càncer de pell
dc.subject	Biòpsia
dc.subject	Quimioteràpia
dc.subject	Skin diseases
dc.subject	Skin cancer
dc.subject	Biopsy
dc.subject	Chemotherapy
dc.title	Monitoring treatment of field cancerisation with 3% diclofenac sodium 2.5% hyaluronic acid by reflectance confocal microscopy: a histologic correlation
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Visual inspection may fail to accurately evaluate field cancerisation (subclinical actinic keratoses [AKs]). We aimed to describe field cancerisation by confocal reflectance microscopy and changes induced by the application of 3% diclofenac sodium gel in 2.5% hyaluronic acid. Fourteen male patients, > 50 years old, with AKs on the bald scalp were included. Clinical examination, confocal microscopy and histological study of clinically visible lesions and 'normal appearing' adjacent skin before and after treatment was completed. Reflectance confocal microscopy showed a decrease in scaling (p = 0.001) and atypia of the honeycomb pattern (p = 0.001) at 2 weeks of treatment. Changes in parakeratosis, inflammation and dermal collagen remodelling were also observed. Histology correlated with confocal features in AK and subclinical AK. Reflectance confocal microscopy was useful in the evaluation of field cancerisation and monitoring of treatment response. A rapid improvement in epidermal atypia was observed.

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