Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet

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RECERCAT Home > Universitat de Barcelona > Medicina > Articles publicats en revistes (Medicina) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/108590

dc.contributor	Universitat de Barcelona
dc.contributor.author	Figueroa, Ana Lucia
dc.contributor.author	Figueiredo, Hugo
dc.contributor.author	Rebuffat, Sandra A.
dc.contributor.author	Vieira, Elaine
dc.contributor.author	Gomis, Ramon, 1946-
dc.date	2017-03-17T16:15:50Z
dc.date	2017-03-17T16:15:50Z
dc.date	2016-11-18
dc.date	2017-03-17T16:15:50Z
dc.identifier.citation	2045-2322
dc.identifier.citation	669656
dc.identifier.uri	http://hdl.handle.net/2445/108590
dc.description.abstract	Close ties have been made among certain nutrients, obesity, type 2 diabetes and circadian clocks. Among nutrients, taurine has been documented as being effective against obesity and type 2 diabetes. However, the impact of taurine on circadian clocks has not been elucidated. We investigated whether taurine can modulate or correct disturbances in daily rhythms caused by a high-fat diet in mice. Male C57BL/6 mice were divided in four groups: control (C), control + taurine (C+T), high-fat diet (HFD) and HFD + taurine (HFD+T). They were administered 2% taurine in their drinking water for 10 weeks. Mice were euthanized at 6:00, 12:00, 18:00, and 24:00. HFD mice increased body weight, visceral fat and food intake, as well as higher levels of glucose, insulin and leptin, throughout the 24 h. Taurine prevented increments in food intake, body weight and visceral fat, improved glucose tolerance and insulin sensitivity and reduced disturbances in the 24 h patterns of plasma insulin and leptin. HFD downregulated the expression of clock genes Rev-erbα, Bmal1, and Per1 in pancreatic islets. Taurine normalized the gene and protein expression of PER1 in beta-cells, which suggests that it could be beneficial for the correction of daily rhythms and the amelioration of obesity and diabetes.
dc.format	13 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Nature Publishing Group
dc.relation	Reproducció del document publicat a: https://doi.org/10.1038/srep36801
dc.relation	Scientific Reports, 2016, vol. 18, num. 6, p. 36801
dc.relation	https://doi.org/10.1038/srep36801
dc.rights	cc-by (c) Figueroa, Ana Lucia et al., 2016
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.subject	Obesitat
dc.subject	Taurina
dc.subject	Diabetis
dc.subject	Obesity
dc.subject	Taurine
dc.subject	Diabetes
dc.title	Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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