dc.contributor |
Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica |
dc.contributor |
Universitat Politècnica de Catalunya. IEB - Instrumentació Electrònica i Biomèdica |
dc.contributor.author |
Amoros Figueras, Gerard |
dc.contributor.author |
Jorge, Esther |
dc.contributor.author |
García Sánchez, Tomás |
dc.contributor.author |
Bragós Bardia, Ramon |
dc.contributor.author |
Rosell Ferrer, Francisco Javier |
dc.contributor.author |
Cinca Cuscullola, Juan Maria |
dc.date |
2016-08-31 |
dc.identifier.citation |
Amoros, G., Jorge, E., García-Sánchez, T., Bragos, R., Rosell, F., Cinca, J. Recognition of fibrotic infarct density by the pattern of local systolic-diastolic myocardial electrical impedance. "Frontiers in Physiology", 31 Agost 2016, vol. 2016, núm. 7, p. 1-10. |
dc.identifier.citation |
1664-042X |
dc.identifier.citation |
10.3389/fphys.2016.00389 |
dc.identifier.citation |
27630580 |
dc.identifier.uri |
http://hdl.handle.net/2117/99738 |
dc.language.iso |
eng |
dc.relation |
http://journal.frontiersin.org/article/10.3389/fphys.2016.00389/full |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject |
Àrees temàtiques de la UPC::Enginyeria biomèdica::Aparells mèdics::Aparells cardiovasculars |
dc.subject |
Àrees temàtiques de la UPC::Enginyeria electrònica |
dc.subject |
Impedance (Electricity) |
dc.subject |
Cardiology -- Research |
dc.subject |
Healed myocardial infarction |
dc.subject |
Myocardial electrical impedance |
dc.subject |
Bioimpedance |
dc.subject |
Biomedical engineering |
dc.subject |
Impedància (Electricitat) |
dc.subject |
Cardiologia -- Investigació |
dc.title |
Recognition of fibrotic infarct density by the pattern of local systolic-diastolic myocardial electrical impedance |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.type |
info:eu-repo/semantics/article |
dc.description.abstract |
Myocardial electrical impedance is a biophysical property of the heart that is influenced by the intrinsic structural characteristics of the tissue. Therefore, the structural derangements elicited in a chronic myocardial infarction should cause specific changes in the local systolic-diastolic myocardial impedance, but this is not known. This study aimed to characterize the local changes of systolic-diastolic myocardial impedance in a healed myocardial infarction model. Six pigs were successfully submitted to 150 min of left anterior descending (LAD) coronary artery occlusion followed by reperfusion. 4 weeks later, myocardial impedance spectroscopy (1–1000 kHz) was measured at different infarction sites. The electrocardiogram, left ventricular (LV) pressure, LV dP/dt, and aortic
blood flow (ABF) were also recorded. A total of 59 LV tissue samples were obtained and histopathological studies were performed to quantify the percentage of fibrosis.
Samples were categorized as normal myocardium (<10% fibrosis), heterogeneous scar (10–50%) and dense scar (>50%). Resistivity of normal myocardium depicted phasic changes during the cardiac cycle and its amplitude markedly decreased in dense scar (18 ± 2 ·cm vs. 10 ± 1 ·cm, at 41 kHz; P < 0.001, respectively). The mean phasic resistivity decreased progressively from normal to heterogeneous and dense scar regions (285 ± 10 ·cm, 225 ± 25 ·cm, and 162 ± 6 ·cm, at 41 kHz; P < 0.001 respectively).
Moreover, myocardial resistivity and phase angle correlated significantly with the degree of local fibrosis (resistivity: r = 0.86 at 1 kHz, P < 0.001; phase angle: r = 0.84 at 41 kHz, P < 0.001). Myocardial infarcted regions with greater fibrotic content show lower mean impedance values and more depressed systolic-diastolic dynamic impedance changes.
In conclusion, this study reveals that differences in the degree of yocardial fibrosis can be detected in vivo by local measurement of phasic systolic-diastolic bioimpedance spectrum. Once this new bioimpedance method could be used via a catheter-based device, it would be of potential clinical applicability for the recognition of fibrotic tissue to guide the ablation of atrial or ventricular arrhythmias. |
dc.description.abstract |
Award-winning |