Molecular interplay betweeen cáncer cell fatty acid metabolism and oncogenic signaling as resource for novel treatment strategies against ovarian cancer

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RECERCAT Home > Universitat de Barcelona > Química Inorgànica i Orgànica > Articles publicats en revistes (Química Inorgànica i Orgànica) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/97402

dc.contributor	Universitat de Barcelona
dc.contributor.author	Wagner, Renate
dc.contributor.author	Veigel, Daniel
dc.contributor.author	Prostling, K.
dc.contributor.author	Stübiger, Gerald
dc.contributor.author	Grusch, Michael
dc.contributor.author	Weghuber, J.
dc.contributor.author	Singer, C.
dc.contributor.author	Karlic, H.
dc.contributor.author	Colomer, Ramón
dc.contributor.author	López-Rodríguez, María Luz
dc.contributor.author	Benhamú, Bellinda
dc.contributor.author	Hegardt, Fausto
dc.contributor.author	Serra i Cucurull, Dolors
dc.contributor.author	García Gómez, Jordi
dc.contributor.author	Valent, Peter
dc.contributor.author	Grunt, Thomas
dc.date	2016-04-14T09:59:33Z
dc.date	2016-09-29T22:01:15Z
dc.date	2015-09-28
dc.date	2016-04-14T09:59:39Z
dc.identifier.citation	0959-8049
dc.identifier.citation	657043
dc.identifier.uri	http://hdl.handle.net/2445/97402
dc.format	1 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Elsevier B.V.
dc.relation	Versió postprint del document publicat a: http://dx.doi.org/10.1016/S0959-8049(16)30154-X
dc.relation	European Journal of Cancer, 2015, vol. 51, num. Supplement 3, p. S49-S49
dc.relation	http://dx.doi.org/10.1016/S0959-8049(16)30154-X
dc.rights	cc-by-nc-nd (c) Elsevier B.V., 2015
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es
dc.subject	Trompes de Fal·lopi
dc.subject	Càncer d'ovari
dc.subject	Medicaments antineoplàstics
dc.subject	Àcids grassos
dc.subject	Fallopian tubes
dc.subject	Ovarian cancer
dc.subject	Antineoplastic agents
dc.subject	Fatty acids
dc.title	Molecular interplay betweeen cáncer cell fatty acid metabolism and oncogenic signaling as resource for novel treatment strategies against ovarian cancer
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion
dc.description.abstract	The metabolic oncogene fatty acid synthase (FASN) is overexpressed in 80% of ovarian cancers (OC) and indicates poor prognosis. Exposure of OC to inhibitors of FASN elicits a complex stress response that interferes with receptor-PI3K-mTORC1 signaling (briefly designated 'PI3K pathway'). Here we demonstrate that FASN inhibitors capitalize on multiple mechanisms to interfere with the PI3K pathway, and that silencing this cascade is crucial for the anticancer action of the drugs.

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