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Serotonin is involved in the psychostimulant and hypothermic effect of 4-methylamphetamine in rats.
Rubio, Mar; López Arnau, Raúl; Pubill Sánchez, David; Escubedo Rafa, Elena; Camarasa García, Jordi
Universitat de Barcelona
4-Methylamphetamine (4-MA) has recently emerged as a designer drug of abuse in Europe and it is consumed always with amphetamine. There have been reported some deaths and non-fatal intoxications related to 4-MA. We investigated the changes in locomotor activity and body temperature after 4-MA administration to male Sprague-Dawley rats. Our experiments were carried out at a normal or high ambient temperature. 4-MA (2.5-10 mg/Kg, given subcutaneously) increased, in a dose-dependent manner, the horizontal locomotor activity that was significantly reduced by ketanserin, p-cholorophenylalanine (pCPA) or haloperidol, but not by pindolol. In addition, we have studied the effect of 4-MA on core body temperature by means of an implanted electronic thermograph, enabling continuous measurement of body temperature. We observed a dose-dependent hypothermic response to 4-MA that reached a maximum 45 min after a single injection. We also evidenced slight tachyphylaxis to the hypothermic effect when 4-MA was administered four times in a 2 h interval. The pre-treatment of animals with pCPA or pindolol, but not with ketanserin, fully abolished the hypothermic effect of 4-MA. With all that, we conclude that hypothermia induced by 4-MA is due to the release of 5-HT which activates postsynaptic 5-HT1A receptors.
Amfetamines
Farmacologia
Hipotèrmia
Sistema nerviós central
Serotonina
Amphetamines
Pharmacology
Hypothermia
Central nervous system
Serotonin
(c) Elsevier B.V., 2015
Artículo
info:eu-repo/semantics/acceptedVersion
Elsevier B.V.
         

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