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Synthesis and properties of Poly(L-lactide)-b-poly (L-phenylalanine) hybrid copolymers
Planellas Oates, Marc; Puiggalí Bellalta, Jordi
Universitat Politècnica de Catalunya. Departament d'Enginyeria Química; Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.
Hybrid materials constituted by peptides and synthetic polymers have nowadays a great interest since they can combine the properties and functions of each constitutive block, being also possible to modify the final characteristics by using different topologies. Poly(L-lactide-b-L-phenylalanine) copolymers with various block lengths were synthesized by sequential ring-opening polymerization of L-lactide and the N-carboxyanhydride of L-phenylalanine. The resulting block copolymers were characterized by NMR spectrometry, IR spectroscopy, gel permeation chromatography, MALDI-TOF and UV-vis, revealing the successful incorporation of the polyphenylalanine (PPhe) peptide into the previously formed poly(L-lactide) (PLLA) polymer chain. X-ray diffraction and DSC data also suggested that the copolymers were phase-separated in domains containing either crystalline PLLA or PPhe phases. A peculiar thermal behavior was also found by thermogravimetric analysis when polyphenylalanine blocks were incorporated into polylactide.
Peer Reviewed
Àrees temàtiques de la UPC::Enginyeria química
Polymers--Biodegradation
Ring-opening polymerization
biodegradable polymers
block copolymers
self-assembly
polylactide
polyphenylalanine
ring-opening polymerization
SELF-ASSEMBLY PROPERTIES
BLOCK-COPOLYMERS
N-CARBOXYANHYDRIDES
TRIBLOCK COPOLYMER
ACID)
POLYLACTIDE
PEPTIDE
POLYMERIZATION
POLYPEPTIDES
POLYMERS
Polímers -- Biodegradació
Polimerització -- Anàlisi
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/publishedVersion
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