Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell

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dc.contributor	Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.contributor.author	Cascales, L.
dc.contributor.author	Mas Moruno, Carlos
dc.contributor.author	Tamborero, Silvia
dc.contributor.author	Aceña, J.L.
dc.contributor.author	Sanz, J.F.
dc.contributor.author	Fustero, S.
dc.contributor.author	Cruz, Luis Javier
dc.contributor.author	Albericio, Fernando
dc.contributor.author	Mora, P.
dc.contributor.author	Pérez-Payá, Enrique
dc.date	2008
dc.identifier.citation	Cascales, L. [et al.]. Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell. "Chemical biology and drug design", 2008, vol. 72, núm. 4, p. 320-328.
dc.identifier.citation	1747-0277
dc.identifier.citation	10.1111/j.1747-0285.2008.00703.x
dc.identifier.uri	http://hdl.handle.net/2117/22809
dc.language.iso	eng
dc.relation	http://onlinelibrary.wiley.com/doi/10.1111/j.1747-0285.2008.00703.x/abstract
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Enginyeria dels materials
dc.subject	Drugs--Design
dc.subject	endotoxin
dc.subject	lipid A
dc.subject	lipopolysaccharide
dc.subject	lipopolysaccharide-antagonists
dc.subject	sepsis
dc.subject	septic shock
dc.subject	tumour necrosis factor-a
dc.subject	Medicaments -- Disseny
dc.title	Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	The screening of a commercially available library of compounds has proved a successful strategy for the identification of a lead compound in a drug discovery programme. Here, we analysed 880 off-patent drugs, which initially comprised the Prestwick Chemical library, as sources of bacterial endotoxin neutralizers. We identified 3,3',5-triiodo-thyroacetic acid (tiratricol) as a non-antibacterial compound that neutralizes the toxic lipopolysaccharide.
dc.description.abstract	Peer Reviewed

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