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Relaxation dynamics and frequency response of a noisy cell signaling network
Rue Queralt, Pau; Pons Rivero, Antonio Javier; Domedel Puig, Núria; García Ojalvo, Jordi
Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear; Universitat Politècnica de Catalunya. DONLL - Dinàmica no lineal, òptica no lineal i làsers
We investigate the dynamics of cell signaling using an experimentally based Boolean model of the human fibroblast signal transduction network. We determine via systematic numerical simulations the relaxation dynamics of the network in response to a constant set of inputs, both in the absence and in the presence of environmental fluctuations. We then study the network’s response to periodically modulated signals, uncovering different types of behaviors for different pairs of driven input and output nodes. The phenomena observed include low-pass, high-pass, and band-pass filtering of the input modulations, among other nontrivial responses, at frequencies around the relaxation frequency of the network. The results reveal that the dynamic response to the external modulation of biologically realistic signaling networks is versatile and robust to noise.
Peer Reviewed
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Anatomia i fisiologia humana
Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
Fibroblasts -- Analysis -- Mathematical models
Fibroblast -- Models matemàtics
info:eu-repo/semantics/publishedVersion
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