5-HTTLPR polymorphism, mood disorders and MDMA use in a 3-year follow-up study

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dc.contributor	Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa
dc.contributor	Universitat Politècnica de Catalunya. GREMA - Grup de Recerca en Estadística Matemàtica i les seves Aplicacions
dc.contributor.author	de la Torre, Rafael
dc.contributor.author	Martín-Santos, Rocío
dc.contributor.author	Torrens, M.
dc.contributor.author	Poudevida, Sandra
dc.contributor.author	Langohr, Klaus
dc.contributor.author	Cuyas, Elisabet
dc.contributor.author	Pacifici, Roberta
dc.contributor.author	Farré, Magí
dc.contributor.author	Pichini, Simona
dc.date	2010-01
dc.identifier.citation	Martín-Santos, R. [et al.]. 5-HTTLPR polymorphism, mood disorders and MDMA use in a 3-year follow-up study. "Addiction biology", Gener 2010, vol. 15, núm. 1, p. 15-22.
dc.identifier.citation	1355-6215
dc.identifier.citation	10.1111/j.1369-1600.2009.00180.x
dc.identifier.uri	http://hdl.handle.net/2117/9071
dc.language.iso	eng
dc.relation	http://onlinelibrary.wiley.com/doi/10.1111/j.1369-1600.2009.00180.x/abstract
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària
dc.subject	Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica::Anàlisi multivariant
dc.subject	Affective disorders
dc.subject	Cannabis
dc.subject	Ecstasy (Drug)
dc.subject	Substance abuse
dc.subject	Cànnabis
dc.subject	Èxtasi
dc.subject	Drogues
dc.subject	Afecte (Psicologia)
dc.title	5-HTTLPR polymorphism, mood disorders and MDMA use in a 3-year follow-up study
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	A 3-year longitudinal prospective study was conducted to compare the incidence of substance use disorders (SUD) and non-substance use disorders (NSUD) among ecstasy users and two control groups: one of cannabis users and the other of non-drug users. The 5-HTTLPR polymorphism related to NSUD was also studied. A total of 94 subjects were included: 37 ecstasy users, 23 cannabis users and 34 non-drug users. SUD and NSUD disorders were diagnosed according to the fourth edition of the Diagnostic and Statistical Manual of Mental Health Disorders criteria using the Psychiatric Research Interview for Substance and Mental Disorders. Incidence Rates (IR) are presented. The 5-HTTLPR polymorphism was analyzed. Hardy–Weinberg equilibrium was studied. The results of the study showed that the highest IR of SUD was cannabis abuse/dependence in both the ecstasy (IR: 48.6/100 person–year) and cannabis (IR: 2.5/100 person–year) groups. Therewere no new cases of SUD in non-drug users at follow-up. The highest IR of NSUD was primary mood disorder in both the ecstasy (IR: 4.2/100 person–year) and in the non-drug (IR: 1.3/100 person– year) groups (P < 0.282). There were no new cases of NSUD in the cannabis group at follow-up. 5-HTTLPR polymorphism was associated with lifetime of primarymood disorders in ecstasy group (P = 0.018). Ecstasy use was associated with a higher rate of cannabis abuse/dependence disorders and mood disorders than cannabis use. In the ecstasy users, 5-HTTLPR polymorphism may result in a high vulnerability to primary mood disorders.

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