Immunoelectron microscopic localization of transforming growth factor alpha in rat colon

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dc.contributor	Universitat de Barcelona
dc.contributor.author	Pérez Tomás, Ricardo E.
dc.contributor.author	Culleré i Luengo, F. Xavier
dc.contributor.author	Asbert i Alsina, Mònica
dc.contributor.author	Díaz Ruiz, Carmen
dc.date	2011-07-07T11:33:22Z
dc.date	2011-07-07T11:33:22Z
dc.date	1994
dc.identifier.citation	0017-5749
dc.identifier.citation	92908
dc.identifier.uri	http://hdl.handle.net/2445/18639
dc.format	4 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	BMJ Group
dc.relation	Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.35.8.1086
dc.relation	Gut, 1994, vol. 35, núm. 8, p. 1086-1089
dc.relation	http://dx.doi.org/10.1136/gut.35.8.1086
dc.rights	(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1994
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Còlon
dc.subject	Cicle cel·lular
dc.subject	Pèptids
dc.subject	Factors de creixement
dc.subject	Colon
dc.subject	Cell cycle
dc.subject	Peptides
dc.subject	Growth factors
dc.title	Immunoelectron microscopic localization of transforming growth factor alpha in rat colon
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Transforming growth factor alpha (TGF alpha) is a polypeptide, which binds to the epidermal growth factor receptor to carry out its function related to cell proliferation and differentiation. The ultrastructural localisation of TGF alpha was studied in both the proximal and the distal colon. The columnar cells, lining the surface epithelium of the proximal colon, showed a strong immunoreactivity in the polyribosomes and in the interdigitations of the lateral membrane. The columnar cells of the crypts and the goblet cells in both the proximal and the distal colon showed the immunostaining in the cis and trans cisternae of the Golgi apparatus. TGF alpha seems to be processed differently in the surface columnar cells and in the crypt columnar cells and goblet cells. Moreover, it probably has different roles in proliferation and differentiation.

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