Serotypes and clonal composition of streptococcus pneumoniae isolates causing IPD in children and adults in Catalonia before 2013 to 2015 and after 2017 to 2019 systematic introduction of PCV13

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To access the full text documents, please follow this link: http://hdl.handle.net/20.500.12328/3088

dc.contributor.author	Redin, A.
dc.contributor.author	Ciruela, P.
dc.contributor.author	De Sevilla, M. F.
dc.contributor.author	Gomez-Bertomeu, F.
dc.contributor.author	Gonzalez-Peris, S.
dc.contributor.author	Benitez, M. A.
dc.contributor.author	Trujillo, G.
dc.contributor.author	Diaz, A.
dc.contributor.author	Jou, E.
dc.contributor.author	Izquierdo, C.
dc.contributor.author	Perez-Moreno, M. O.
dc.contributor.author	Moraga-Llop, F.
dc.contributor.author	Olsina, M.
dc.contributor.author	Vinado, B.
dc.contributor.author	Sanfeliu, E.
dc.contributor.author	Garcia, A.
dc.contributor.author	Gonzalez-di Lauro, S.
dc.contributor.author	Garcia-Garcia, J. J.
dc.contributor.author	Dominguez, A.
dc.contributor.author	Sa-Leao, R.
dc.contributor.author	Muñoz Almagro, Carmen
dc.contributor.author	Catalan Study Group of Invasive Pneumococcal DiseaseSHOW FEWER
dc.date	2022-01-20T12:12:43Z
dc.date	2022-01-20T12:12:43Z
dc.date	2021
dc.identifier	Redin, A.; Ciruela, P.; De Sevilla, M. F. [et al.]. Serotypes and clonal composition of streptococcus pneumoniae isolates causing IPD in children and adults in Catalonia before 2013 to 2015 and after 2017 to 2019 systematic introduction of PCV13. Microbiology Spectrum, 2021, 9(3), e01150-21. Disponible en: <https://journals.asm.org/doi/10.1128/Spectrum.01150-21>. Fecha de acceso: 20 ene. 2022. DOI: 10.1128/Spectrum.01150-21.
dc.identifier	2165-0497
dc.identifier	http://hdl.handle.net/20.500.12328/3088
dc.identifier	https://dx.doi.org/10.1128/Spectrum.01150-21
dc.identifier.uri	http://hdl.handle.net/20.500.12328/3088
dc.description	The goal of this study was to investigate the distribution of serotypes and clonal composition of Streptococcus pneumoniae isolates causing invasive pneumococcal disease (IPD) in Catalonia, before and after systematic introduction of PCV13. Pneumococcal strains isolated from normally sterile sites obtained from patients of all ages with IPD received between 2013 and 2019 from 25 health centers of Catalonia were included. Two study periods were defined: presystematic vaccination period (2013 and 2015) and systematic vaccination period (SVP) (2017 to 2019). A total of 2,303 isolates were analyzed. In the SVP, there was a significant decrease in the incidence of IPD cases in children 5 to 17 years old (relative risk [RR] 0.61; 95% confidence interval [CI] 0.38 to 0.99), while there was a significant increase in the incidence of IPD cases in 18- to 64-year-old adults (RR 1.33; 95% CI 1.16 to 1.52) and adults over 65 years old (RR 1.23; 95% CI 1.09 to 1.38). Serotype 8 was the major emerging serotype in all age groups except in 5- to 17-year-old children. In children younger than 5 years old, the main serotypes in SVP were 24F, 15A, and 3, while in adults older than 65 years they were serotypes 3, 8, and 12F. A significant decrease in the proportions of clonal complexes CC156, CC191, and ST306 and an increase in those of CC180, CC53, and CC404 were observed. A steady decrease in the incidence of IPD caused by PCV13 serotypes indicates the importance and impact of systematic vaccination. The increase of non-PCV13 serotypes highlights the need to expand serotype coverage in future vaccines and rethink vaccination programs for older adults. IMPORTANCE We found that with the incorporation of the PCV13 vaccine, the numbers of IPD cases caused by serotypes included in this vaccine decreased in all of the age groups. Still, there was an unforeseen increase of the serotypes not included in this vaccine causing IPD, especially in the >65-year-old group. Moreover, a significant increase of serotype 3 included in the vaccine has been observed; this event has been reported by other researchers. These facts call for the incorporation of more serotypes in future vaccines and a more thorough surveillance of the dynamics of this microorganism.
dc.format	14
dc.format	application/pdf
dc.language	eng
dc.publisher	American Society for Microbiology
dc.relation	Microbiology Spectrum
dc.relation	9;3
dc.rights	© 2021 Redin et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
dc.rights	https://creativecommons.org/licenses/by/4.0/
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Serotips
dc.subject	Streptococcus pneumoniae
dc.subject	Malaltia pneumocòcica invasiva
dc.subject	Vacunació
dc.subject	Vacunació presistemàtica
dc.subject	Vacunació sistemàtica
dc.subject	Serotipos
dc.subject	Streptococcus pneumoniae
dc.subject	Enfermedad neumocócica invasiva
dc.subject	Vacunación
dc.subject	Vacunación presistemática
dc.subject	Vacunación sistemática
dc.subject	Serotypes
dc.subject	Streptococcus pneumoniae
dc.subject	Invasive pneumococcal disease
dc.subject	Vaccination
dc.subject	Presystematic vaccination
dc.subject	Systematic vaccination
dc.subject	61
dc.title	Serotypes and clonal composition of streptococcus pneumoniae isolates causing IPD in children and adults in Catalonia before 2013 to 2015 and after 2017 to 2019 systematic introduction of PCV13
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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