Título:
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Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era
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Autor/a:
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Izquierdo, Conchita; Ciruela, Pilar; Hernández, S.; García-García, J. J.; Esteva, C.; Moraga-Llop, F.; Díaz-Conradi, A.; Martínez-Osorio, J.; Solé-Ribalta, A.; de Sevilla, M. F.; González-Peris, S.; Codina, María Gema; Planes, A. M.; Uriona, S.; Campins Martí, Magda; Muñoz-Almagro, C.; Salleras, L.; Domínguez, Ángela; Universitat Autònoma de Barcelona
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Abstract:
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The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study (January 2012-June 2016). IPD cases were diagnosed by culture and/or real-time polymerase chain reaction (PCR). Demographic, microbiological and clinical data were analysed. Associations were assessed using the odds ratio (OR) and 95% confidence intervals (CI). Of the 253 cases, 34.4% were aged <2 years, 38.7% 2-4 years and 26.9% 5-17 years. Over 64% were 13-valent pneumococcal conjugate vaccine (PCV13) serotypes. 48% of the cases were diagnosed only by real-time PCR. Serotypes 3 and 1 were associated with complicated pneumonia (P < 0.05) and non-PCV13 serotypes with meningitis (OR 7.32, 95% CI 2.33-22.99) and occult bacteraemia (OR 3.6, 95% CI 1.56-8.76). Serotype 19A was more frequent in children aged <2 years and serotypes 3 and 1 in children aged 2-4 years and 5-17 years, respectively. 36.1% of cases were not susceptible to penicillin and 16.4% were also non-susceptible to cefotaxime. Serotypes 14, 24F and 23B were associated with non-susceptibility to penicillin (P < 0.05) and serotypes 11, 14 and 19A to cefotaxime (P < 0.05). Serotype 19A showed resistance to penicillin (P = 0.002). In conclusion, PCV13 serotypes were most frequent in children aged ⩽17 years, mainly serotypes 3, 1 and 19A. Non-PCV13 serotypes were associated with meningitis and occult bacteraemia and PCV13 serotypes with pneumonia. Non-susceptibility to antibiotics of non-PCV13 serotypes should be monitored PI11/02081 and PI11/02345) |
Materia(s):
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-Antimicrobial susceptibility -Invasive pneumococcal disease -PCV13 vaccine -Penicillin resistance -Serotype distribution -Streptococcus pneumoniae |
Derechos:
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open access
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Article |
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Uri:
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https://ddd.uab.cat/record/253054
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