Biofunctionalization strategies on tantalum-based materials for osseointegrative applications

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RECERCAT Home > Universitat Internacional de Catalunya > Recerca > Articles > Ciències de la Salut > View document

To access the full text documents, please follow this link: http://hdl.handle.net/20.500.12328/2541

dc.contributor.author	Mas Moruno, Carlos
dc.contributor.author	Garrido, Beatriz
dc.contributor.author	Rodriguez, Daniel
dc.contributor.author	Rupérez de Gracia, Elisa
dc.contributor.author	Gil Mur, Francisco Javier
dc.date	2021-05-14T14:57:10Z
dc.date	2021-05-14T14:57:10Z
dc.date	2015
dc.identifier	Mas-Moruno, Carlos; Garrido, Beatriz; Rodriguez, Daniel [et al.]. Biofunctionalization strategies on tantalum-based materials for osseointegrative applications. Journal of Materials Science: Materials in Medicine, 2015, 26, 109. Disponible en: <https://link.springer.com/article/10.1007/s10856-015-5445-z>. Fecha de acceso: 14 may. 2021. DOI: 10.1007/s10856-015-5445-z
dc.identifier	1573-4838
dc.identifier	http://hdl.handle.net/20.500.12328/2541
dc.identifier	https://dx.doi.org/10.1007/s10856-015-5445-z
dc.identifier.uri	http://hdl.handle.net/20.500.12328/2541
dc.description	The use of tantalum as biomaterial for orthopedic applications is gaining considerable attention in the clinical practice because it presents an excellent chemical stability, body fluid resistance, biocompatibility, and it is more osteoconductive than titanium or cobalt-chromium alloys. Nonetheless, metallic biomaterials are commonly bioinert and may not provide fast and long-lasting interactions with surrounding tissues. The use of short cell adhesive peptides derived from the extracellular matrix has shown to improve cell adhesion and accelerate the implant’s biointegration in vivo. However, this strategy has been rarely applied to tantalum materials. In this work, we have studied two immobilization strategies (physical adsorption and covalent binding via silanization) to functionalize tantalum surfaces with a cell adhesive RGD peptide. Surfaces were used untreated or activated with either HNO3 or UV/ozone treatments. The process of biofunctionalization was characterized by means of physicochemical and biological methods. Physisorption of the RGD peptide on control and HNO3-treated tantalum surfaces significantly enhanced the attachment and spreading of osteoblast-like cells; however, no effect on cell adhesion was observed in ozone-treated samples. This effect was attributed to the inefficient binding of the peptide on these highly hydrophilic surfaces, as evidenced by contact angle measurements and X-ray photoelectron spectroscopy. In contrast, activation of tantalum with UV/ozone proved to be the most efficient method to support silanization and subsequent peptide attachment, displaying the highest values of cell adhesion. This study demonstrates that both physical adsorption and silanization are feasible methods to immobilize peptides onto tantalum-based materials, providing them with superior bioactivity.
dc.format	12
dc.format	application/pdf
dc.language	eng
dc.publisher	Springer Nature
dc.relation	Journal of Materials Science: Materials in Medicine
dc.relation	26;
dc.relation	info:eu-repo/grantAgreement/MINECO/6PN/MAT2012-30706
dc.relation	info:eu-repo/grantAgreement/EC/FP7/321985
dc.rights	This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
dc.rights	https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Materials biomèdics
dc.subject	Ortopèdia
dc.subject	Titani
dc.subject	Cobalt
dc.subject	Crom
dc.subject	Implants artificials
dc.subject	Biocompatibilitat
dc.subject	Materiales biomédicos
dc.subject	Ortopedia
dc.subject	Titanio
dc.subject	Cobalto
dc.subject	Cromo
dc.subject	Implantes artificiales
dc.subject	Biocompatibilidad
dc.subject	Biomedical materials
dc.subject	Orthopedics
dc.subject	Titanium
dc.subject	Cobalt
dc.subject	Chrome
dc.subject	Artificial implants
dc.subject	Biocompatibility
dc.subject	61
dc.subject	620
dc.title	Biofunctionalization strategies on tantalum-based materials for osseointegrative applications
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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