Mechanical and physicochemical characterization along with biological interactions of a new Ti25Nb21Hf alloy for bone tissue engineering

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RECERCAT Home > Universitat Internacional de Catalunya > Recerca > Articles > Ciències de la Salut > View document

To access the full text documents, please follow this link: http://hdl.handle.net/20.500.12328/1515

dc.contributor.author	Herranz-Diez, Carolina
dc.contributor.author	Gil Mur, Francisco Javier
dc.contributor.author	Guillem Martí, Jordi
dc.contributor.author	Manero Planella, José María
dc.date	2020-05-09T14:29:13Z
dc.date	2020-05-09T14:29:13Z
dc.date	2015-03-23
dc.identifier	Herranz-Diez, C.; Gil Mur, F.J.; Guillem-Marti, J. [et al.]. Mechanical and physicochemical characterization along with biological interactions of a new Ti25Nb21Hf alloy for bone tissue engineering. Journal of Biomaterials Applications, 2015, 30(2), p. 171-181. Disponible en: <https://journals.sagepub.com/doi/abs/10.1177/0885328215577524?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=jbaa>. Fecha de acceso: 9 may 2020. DOI: 10.1177/0885328215577524
dc.identifier	0885-3282
dc.identifier	https://dx.doi.org/10.1177/0885328215577524
dc.identifier.uri	http://hdl.handle.net/20.500.12328/1515
dc.description	Nowadays, one of the main challenges in metal implants for bone substitution is the achievement of an elastic modulus close to that of human cortical bone as well as to provide an adequate interaction with the surrounding tissue avoiding in vivo foreign body reaction. From this perspective, a new Ti-based alloy has been developed with Nb and Hf as alloying elements which are known as non-toxic and with good corrosion properties. The microstructure, mechanical behaviour and the physicochemical properties of this novel titanium alloy have been studied. Relationship of surface chemistry and surface electric charge with protein adsorption and cell adhesion has been evaluated due to its role for understanding the mechanism of biological interactions with tissues. The Ti25Nb21Hf alloy presented a lower elastic modulus than commercial alloys with a superior ultimate strength and yield strength than CP-Ti and very close to Ti6Al4V. It also exhibited good corrosion resistance. Furthermore, the results revealed that it had no cytotoxic effect on rat mesenchymal stem cells and allowed protein adsorption and cell adhesion. The experimental results make this alloy a promising material for bone substitution or for biomedical devices.
dc.format	31
dc.format	application/pdf
dc.language	eng
dc.publisher	SAGE Publications
dc.relation	Journal of Biomaterials Applications
dc.relation	30;2
dc.relation	info:eu-repo/grantAgreement/MINECO/6PN/MAT2012-30706
dc.rights	© 2020 by SAGE Publications
dc.subject	Cèl·lules
dc.subject	Titani
dc.subject	Proteïnes
dc.subject	Electroquímica
dc.subject	Células
dc.subject	Titanio
dc.subject	Proteínas
dc.subject	Electroquímica
dc.subject	Cells
dc.subject	Titanium
dc.subject	Proteins
dc.subject	Electrochemistry
dc.subject	57
dc.title	Mechanical and physicochemical characterization along with biological interactions of a new Ti25Nb21Hf alloy for bone tissue engineering
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion

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