Finding MYCure

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RECERCAT Home > Sistema de Salut de Catalunya > Vall d'Hebron Institut d'Oncologia – VHIO > Articles científics - VHIO > View document

To access the full text documents, please follow this link: http://hdl.handle.net/11351/5775

dc.contributor	Institut Català de la Salut
dc.contributor	[Beaulieu ME] Peptomyc S.L., Edifici Cellex, Barcelona, Spain. [Soucek L] Peptomyc S.L., Edifici Cellex, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.contributor	Hospital Universitari Vall d'Hebron
dc.contributor.author	Beaulieu, Marie-Eve
dc.contributor.author	Soucek, Laura
dc.date	2021-03-19T09:43:19Z
dc.date	2021-03-19T09:43:19Z
dc.date	2019-06-20
dc.identifier	Beaulieu ME, Soucek L. Finding MYCure. Mol Cell Oncol. 2019 Jun 20;6(5):e1618178.
dc.identifier	2372-3556
dc.identifier	http://hdl.handle.net/11351/5775
dc.identifier	10.1080/23723556.2019.1618178
dc.identifier	31528695
dc.identifier	000485086600009
dc.identifier.uri	http://hdl.handle.net/11351/5775
dc.format	application/pdf
dc.language	eng
dc.publisher	Taylor and Francis
dc.relation	Molecular & Cellular Oncology;6(5)
dc.relation	https://www.tandfonline.com/doi/full/10.1080/23723556.2019.1618178
dc.relation	info:eu-repo/grantAgreement/ES/PE2013-2016/PI13%2F01705
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights	info:eu-repo/semantics/openAccess
dc.source	Scientia
dc.subject	Pèptids
dc.subject	Oncogens
dc.subject	CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Peptide Fragments
dc.subject	Other subheadings::Other subheadings::Other subheadings::/administration & dosage
dc.subject	CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Basic Helix-Loop-Helix Transcription Factors::Proto-Oncogene Proteins c-myc
dc.subject	COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::fragmentos peptídicos
dc.subject	Otros calificadores::Otros calificadores::Otros calificadores::/administración & dosificación
dc.subject	COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de unión al ADN::factores de transcripción con hélice-asa-hélice básico::proteínas protooncogénicas c-myc
dc.title	Finding MYCure
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	MYC; Peptide therapeutic; Mini-protein
dc.description.abstract	MYC; Péptido terapéutico; Mini-proteína
dc.description.abstract	MYC; Pèptid terapèutic; Mini-proteïna
dc.description.abstract	Inhibiting the nuclear protein MYC involved in the majority of human cancers has long been considered an impossible mission and several technical challenges have discouraged the development of MYC inhibitory strategies. Nevertheless, in our recent publication in Science Translational Medicine "Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy", we demonstrate for the first time the feasibility of pharmacological MYC inhibition in vitro and in vivo using an Omomyc-based mini-protein.
dc.description.abstract	This work was supported by the European Research Council [617473];Instituto de Salud Carlos III [PI13/01705]; BBVA Foundation [67_2015];Worlwide Cancer Research [13-1182].

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