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Título:
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Finding MYCure
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Autor/a:
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Beaulieu, Marie-Eve; Soucek, Laura
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Otros autores:
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Institut Català de la Salut; [Beaulieu ME] Peptomyc S.L., Edifici Cellex, Barcelona, Spain. [Soucek L] Peptomyc S.L., Edifici Cellex, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain; Hospital Universitari Vall d'Hebron |
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Abstract:
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MYC; Peptide therapeutic; Mini-protein |
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Abstract:
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MYC; Péptido terapéutico; Mini-proteína |
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Abstract:
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MYC; Pèptid terapèutic; Mini-proteïna |
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Abstract:
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Inhibiting the nuclear protein MYC involved in the majority of human cancers has long been considered an impossible mission and several technical challenges have discouraged the development of MYC inhibitory strategies. Nevertheless, in our recent publication in Science Translational Medicine "Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy", we demonstrate for the first time the feasibility of pharmacological MYC inhibition in vitro and in vivo using an Omomyc-based mini-protein. |
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Abstract:
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This work was supported by the European Research Council [617473];Instituto de Salud Carlos III [PI13/01705]; BBVA Foundation [67_2015];Worlwide Cancer Research [13-1182]. |
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Materia(s):
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-Pèptids
-Oncogens
-CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Peptide Fragments
-Other subheadings::Other subheadings::Other subheadings::/administration & dosage
-CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Basic Helix-Loop-Helix Transcription Factors::Proto-Oncogene Proteins c-myc
-COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::fragmentos peptídicos
-Otros calificadores::Otros calificadores::Otros calificadores::/administración & dosificación
-COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de unión al ADN::factores de transcripción con hélice-asa-hélice básico::proteínas protooncogénicas c-myc |
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Derechos:
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Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Tipo de documento:
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Artículo
Artículo - Versión publicada |
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Editor:
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Taylor and Francis
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Compartir:
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