The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer

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RECERCAT Home > Sistema de Salut de Catalunya > Vall d'Hebron Institut d'Oncologia – VHIO > Articles científics - VHIO > View document

To access the full text documents, please follow this link: http://hdl.handle.net/11351/4255

dc.contributor	Institut Català de la Salut
dc.contributor	[De Mattos-Arruda L] Department of Oncology and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK. University of Cambridge, Cambridge, UK. Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Sammut SJ, Ross EM] Department of Oncology and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK. University of Cambridge, Cambridge, UK. [Bashford-Rogers R] Department of Medicine, University of Cambridge, Cambridge, UK. [Greenstein E] Department of Immunology, Weizmann Institute of Science, Rehovot, Israel. [Markus H] Center for Noninvasive Diagnostics, Translational Genomics Research Institute, Phoenix, USA. Mayo Clinic Center for Individualized Medicine, Scottsdale, USA. [Mayor R, Arias A] Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. Spanish Biomedical Research Network Centre in Oncology (CIBERONC), Madrid, Spain. [Ciriaco N] Servei d’Anatomia Patològica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Martinez-Saez E] Spanish Biomedical Research Network Centre in Oncology (CIBERONC), Madrid, Spain. Servei d’Anatomia Patològica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Peg V, Ramon Y Cajal S] Spanish Biomedical Research Network Centre in Oncology (CIBERONC), Madrid, Spain. Servei d’Anatomia Patològica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Cortes J] Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. Ramon y Cajal Hospital, Madrid, Spain. [Seoane J] Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. Spanish Biomedical Research Network Centre in Oncology (CIBERONC), Madrid, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
dc.contributor	Hospital Universitari Vall d'Hebron
dc.contributor.author	Mattos Arruda, Leticia de
dc.contributor.author	Sammut, Stephen-John
dc.contributor.author	Ross, Edith M
dc.contributor.author	Bashford-Rogers, Rachael
dc.contributor.author	Greenstein, Erez
dc.contributor.author	Markus, Havell
dc.contributor.author	Mayor Ferreras, Regina Gabriela
dc.contributor.author	Arias Piñeiro, Alexandra
dc.contributor.author	Ciriaco Cortes, Nikaoly de los angel
dc.contributor.author	Martinez Saez, Elena Antima
dc.contributor.author	Peg Camara, Vicente
dc.contributor.author	Ramon y Cajal Agüeras, Santiago
dc.contributor.author	Cortés Castan, Javier
dc.contributor.author	Seoane Suarez, Joan
dc.date	2019-08-08T06:29:26Z
dc.date	2019-08-08T06:29:26Z
dc.date	2019-05-28
dc.identifier	De Mattos-Arruda L, Sammut S-J, Ross EM, Bashford-Rogers R, Greenstein E, Markus H, et al. The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer. Cell Rep. 2019; 27(9):2690-2708.
dc.identifier	2211-1247
dc.identifier	10.1016/j.celrep.2019.04.098
dc.identifier	31141692
dc.identifier	WOS:000469216500015
dc.identifier.uri	http://hdl.handle.net/11351/4255
dc.format	application/pdf
dc.language	eng
dc.publisher	Elsevier
dc.relation	Cell Reports;27(9)
dc.relation	https://www.sciencedirect.com/science/article/pii/S2211124719305789?via%3Dihub
dc.rights	Attribution 4.0 International
dc.rights	http://creativecommons.org/licenses/by/4.0/
dc.rights	info:eu-repo/semantics/openAccess
dc.source	Scientia
dc.subject	Mama - Càncer - Aspectes genètics
dc.subject	Mama - Càncer - Aspectes immunològics
dc.subject	Metàstasi
dc.subject	DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
dc.subject	DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Metastasis
dc.subject	Other subheadings::Other subheadings::Other subheadings::/genetics
dc.subject	Other subheadings::Other subheadings::Other subheadings::/immunology
dc.subject	ENFERMEDADES::Neoplasias::Neoplasias por Localización::Neoplasias de la Mama
dc.subject	ENFERMEDADES::neoplasias::procesos neoplásicos::metástasis neoplásica
dc.subject	Otros calificadores::Otros calificadores::Otros calificadores::/genética
dc.subject	Otros calificadores::Otros calificadores::Otros calificadores::/inmunología
dc.title	The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	TCR repertoire; Breast cancer; Clade mutations
dc.description.abstract	Repertori TCR; Càncer de mama; Mutacions clade
dc.description.abstract	Repertorio TCR; Cáncer de mama; Mutaciones clado
dc.description.abstract	The detailed molecular characterization of lethal cancers is a prerequisite to understanding resistance to therapy and escape from cancer immunoediting. We performed extensive multi-platform profiling of multi-regional metastases in autopsies from 10 patients with therapy-resistant breast cancer. The integrated genomic and immune landscapes show that metastases propagate and evolve as communities of clones, reveal their predicted neo-antigen landscapes, and show that they can accumulate HLA loss of heterozygosity (LOH). The data further identify variable tumor microenvironments and reveal, through analyses of T cell receptor repertoires, that adaptive immune responses appear to co-evolve with the metastatic genomes. These findings reveal in fine detail the landscapes of lethal metastatic breast cancer.

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