The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer

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Títol:	The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer
Autor/a:	Mattos Arruda, Leticia de; Sammut, Stephen-John; Ross, Edith M; Bashford-Rogers, Rachael; Greenstein, Erez; Markus, Havell; Mayor Ferreras, Regina Gabriela; Arias Piñeiro, Alexandra; Ciriaco Cortes, Nikaoly de los angel; Martinez Saez, Elena Antima; Peg Camara, Vicente; Ramon y Cajal Agüeras, Santiago; Cortés Castan, Javier; Seoane Suarez, Joan
Altres autors:	Institut Català de la Salut; [De Mattos-Arruda L] Department of Oncology and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK. University of Cambridge, Cambridge, UK. Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Sammut SJ, Ross EM] Department of Oncology and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK. University of Cambridge, Cambridge, UK. [Bashford-Rogers R] Department of Medicine, University of Cambridge, Cambridge, UK. [Greenstein E] Department of Immunology, Weizmann Institute of Science, Rehovot, Israel. [Markus H] Center for Noninvasive Diagnostics, Translational Genomics Research Institute, Phoenix, USA. Mayo Clinic Center for Individualized Medicine, Scottsdale, USA. [Mayor R, Arias A] Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. Spanish Biomedical Research Network Centre in Oncology (CIBERONC), Madrid, Spain. [Ciriaco N] Servei d’Anatomia Patològica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Martinez-Saez E] Spanish Biomedical Research Network Centre in Oncology (CIBERONC), Madrid, Spain. Servei d’Anatomia Patològica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Peg V, Ramon Y Cajal S] Spanish Biomedical Research Network Centre in Oncology (CIBERONC), Madrid, Spain. Servei d’Anatomia Patològica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Cortes J] Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. Ramon y Cajal Hospital, Madrid, Spain. [Seoane J] Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. Spanish Biomedical Research Network Centre in Oncology (CIBERONC), Madrid, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain; Hospital Universitari Vall d'Hebron
Abstract:	TCR repertoire; Breast cancer; Clade mutations
Abstract:	Repertori TCR; Càncer de mama; Mutacions clade
Abstract:	Repertorio TCR; Cáncer de mama; Mutaciones clado
Abstract:	The detailed molecular characterization of lethal cancers is a prerequisite to understanding resistance to therapy and escape from cancer immunoediting. We performed extensive multi-platform profiling of multi-regional metastases in autopsies from 10 patients with therapy-resistant breast cancer. The integrated genomic and immune landscapes show that metastases propagate and evolve as communities of clones, reveal their predicted neo-antigen landscapes, and show that they can accumulate HLA loss of heterozygosity (LOH). The data further identify variable tumor microenvironments and reveal, through analyses of T cell receptor repertoires, that adaptive immune responses appear to co-evolve with the metastatic genomes. These findings reveal in fine detail the landscapes of lethal metastatic breast cancer.
Matèries:	-Mama - Càncer - Aspectes genètics -Mama - Càncer - Aspectes immunològics -Metàstasi -DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms -DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Metastasis -Other subheadings::Other subheadings::Other subheadings::/genetics -Other subheadings::Other subheadings::Other subheadings::/immunology -ENFERMEDADES::Neoplasias::Neoplasias por Localización::Neoplasias de la Mama -ENFERMEDADES::neoplasias::procesos neoplásicos::metástasis neoplásica -Otros calificadores::Otros calificadores::Otros calificadores::/genética -Otros calificadores::Otros calificadores::Otros calificadores::/inmunología
Drets:	Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
Tipus de document:	Article Article - Versió publicada
Publicat per:	Elsevier
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