dc.contributor.author |
Vlierberghe, Pieter Van |
dc.contributor.author |
Ambesi Impiombato, Alberto |
dc.contributor.author |
Keersmaecker, Kim De |
dc.contributor.author |
Hadler, Michael |
dc.contributor.author |
Paietta, Elisabeth |
dc.contributor.author |
Tallman, Martin S. |
dc.contributor.author |
Rowe, Jacob M. |
dc.contributor.author |
Forné Izquierdo, Carles |
dc.contributor.author |
Rué i Monné, Montserrat |
dc.contributor.author |
Ferrando, Adolfo A. |
dc.date |
2016-05-09T08:59:14Z |
dc.date |
2016-05-09T08:59:14Z |
dc.date |
2013 |
dc.date |
10000-01-01 |
dc.identifier |
0006-4971 |
dc.identifier |
https://doi.org/10.1182/blood-2013-03-491092 |
dc.identifier.uri |
http://hdl.handle.net/10459.1/56983 |
dc.description |
Adult T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor
associated with poor outcome. In this study, we analyzed the prognostic relevance of genetic
alterations, immunophenotypic markers, and microarray gene expression signatures in
a panel of 53 adult T-ALL patients treated in the Eastern Cooperative Oncology Group E2993
clinical trial. An early immature gene expression signature, the absence of bi-allelic TCRG
deletion, CD13 surface expression, heterozygous deletions of the short arm of chromosome
17, and mutations in IDH1/IDH2 and DNMT3A genes are associated with poor prognosis in
this series. In contrast, expression of CD8 or CD62L, homozygous deletion of CDKN2A/
CDKN2B, NOTCH1 and/or FBXW7 mutations, and mutations or deletions in the BCL11B tumor suppressor gene were associated with
improved overall survival. Importantly, the prognostic relevance of CD13 expression and homozygous CDKN2A/CDKN2B deletions was
restricted to cortical andmature T-ALLs. Conversely, mutations in IDH1/IDH2 and DNMT3A were specifically associated with poor outcome
in early immature adult T-ALLs. This trial was registered at www.clinicaltrials.gov as #NCT00002514. |
dc.language |
eng |
dc.publisher |
American Society of Hematology |
dc.relation |
Reproducció del document publicat a https://doi.org/10.1182/blood-2013-03-491092 |
dc.relation |
Blood, 2013, vol. 122, núm. 1, p. 74-82 |
dc.rights |
(c) American Society of Hematology, 2013 |
dc.rights |
info:eu-repo/semantics/restrictedAccess |
dc.title |
Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia |
dc.type |
article |
dc.type |
publishedVersion |