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Title:
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Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia
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Author:
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Vlierberghe, Pieter Van; Ambesi Impiombato, Alberto; Keersmaecker, Kim De; Hadler, Michael; Paietta, Elisabeth; Tallman, Martin S.; Rowe, Jacob M.; Forné Izquierdo, Carles; Rué i Monné, Montserrat; Ferrando, Adolfo A.
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Notes:
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Adult T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor
associated with poor outcome. In this study, we analyzed the prognostic relevance of genetic
alterations, immunophenotypic markers, and microarray gene expression signatures in
a panel of 53 adult T-ALL patients treated in the Eastern Cooperative Oncology Group E2993
clinical trial. An early immature gene expression signature, the absence of bi-allelic TCRG
deletion, CD13 surface expression, heterozygous deletions of the short arm of chromosome
17, and mutations in IDH1/IDH2 and DNMT3A genes are associated with poor prognosis in
this series. In contrast, expression of CD8 or CD62L, homozygous deletion of CDKN2A/
CDKN2B, NOTCH1 and/or FBXW7 mutations, and mutations or deletions in the BCL11B tumor suppressor gene were associated with
improved overall survival. Importantly, the prognostic relevance of CD13 expression and homozygous CDKN2A/CDKN2B deletions was
restricted to cortical andmature T-ALLs. Conversely, mutations in IDH1/IDH2 and DNMT3A were specifically associated with poor outcome
in early immature adult T-ALLs. This trial was registered at www.clinicaltrials.gov as #NCT00002514. |
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Rights:
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(c) American Society of Hematology, 2013
info:eu-repo/semantics/restrictedAccess |
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Document type:
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article
publishedVersion |
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Published by:
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American Society of Hematology
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