| dc.contributor.author |
Naudí i Farré, Alba |
| dc.contributor.author |
Jové Font, Mariona |
| dc.contributor.author |
Aledo, Juan Carlos |
| dc.contributor.author |
Ayala Jové, Ma. Victoria (Maria Victoria) |
| dc.contributor.author |
Cabré Cucó, Rosanna |
| dc.contributor.author |
Portero Otín, Manuel |
| dc.contributor.author |
Barja, Gustavo |
| dc.contributor.author |
Pamplona Gras, Reinald |
| dc.date |
2015-11-18T11:17:32Z |
| dc.date |
2015-11-18T11:17:32Z |
| dc.date |
2013 |
| dc.identifier |
2045-2322 |
| dc.identifier |
http://hdl.handle.net/10459.1/48985 |
| dc.identifier |
https://doi.org/10.1038/srep03346 |
| dc.identifier.uri |
http://hdl.handle.net/10459.1/48985 |
| dc.description |
determination of their longevity. In the present work, the use of high-throughput technologies allowed us to
determine the plasma lipidomic profile of 11 mammalian species ranging in maximum longevity from 3.5 to
120 years. The non-targeted approach revealed a specie-specific lipidomic profile that accurately predicts the
animal longevity. The regression analysis between lipid species and longevity demonstrated that the longer
the longevity of a species, the lower is its plasma long-chain free fatty acid (LC-FFA) concentrations,
peroxidizability index, and lipid peroxidation-derived products content. The inverse association between longevity and LC-FFA persisted after correction for body mass and phylogenetic interdependence. These
results indicate that the lipidomic signature is an optimized feature associated with animal longevity, emerging LC-FFA as a potential biomarker of longevity |
| dc.description |
We acknowledge funding from the Spanish Ministry of Science and Innovation (CGL2010-18124) to J.C.A.; from the Spanish Ministry of Health (PI11-01532) to M.P.O.; and from the Spanish Ministry of Science and Innovation (BFU2009-11879/BFI), the Generalitat of Catalonia (2009SGR735), and the La MaratoTV3 Foundation to R.P. R.C. was supported by a Generalitat of Catalonia Predoctoral Fellowship. We thank David Argiles for excellent technical assistance. We thank Dr. Montserrat Rué for her support in statistical analyses. |
| dc.language |
eng |
| dc.publisher |
Nature Publishing Group |
| dc.relation |
MICINN/PN2008-2011/CGL2010-18124 |
| dc.relation |
MICINN/PN2008-2011/PI11-01532 |
| dc.relation |
MICINN/PN2008-2011/BFU2009-11879/BFI |
| dc.relation |
Reproducció del document publicat a https://doi.org/10.1038/srep03346 |
| dc.relation |
Scientific Reports, 2013, vol. 3, p. 1-10 |
| dc.rights |
cc-by-nc-nd (c) Jové Font, Mariona et al., 2013 |
| dc.rights |
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
| dc.rights |
info:eu-repo/semantics/openAccess |
| dc.subject |
Longevity |
| dc.subject |
Plasma long-chain |
| dc.subject |
Metabolism |
| dc.title |
Plasma long-chain free fatty acids predict mammalian longevity |
| dc.type |
article |
| dc.type |
publishedVersion |
