|
Título:
|
Plasma long-chain free fatty acids predict mammalian longevity
|
|
Autor/a:
|
Naudí i Farré, Alba; Jové Font, Mariona; Aledo, Juan Carlos; Ayala Jové, Ma. Victoria (Maria Victoria); Cabré Cucó, Rosanna; Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald
|
|
Notas:
|
determination of their longevity. In the present work, the use of high-throughput technologies allowed us to
determine the plasma lipidomic profile of 11 mammalian species ranging in maximum longevity from 3.5 to
120 years. The non-targeted approach revealed a specie-specific lipidomic profile that accurately predicts the
animal longevity. The regression analysis between lipid species and longevity demonstrated that the longer
the longevity of a species, the lower is its plasma long-chain free fatty acid (LC-FFA) concentrations,
peroxidizability index, and lipid peroxidation-derived products content. The inverse association between longevity and LC-FFA persisted after correction for body mass and phylogenetic interdependence. These
results indicate that the lipidomic signature is an optimized feature associated with animal longevity, emerging LC-FFA as a potential biomarker of longevity
We acknowledge funding from the Spanish Ministry of Science and Innovation (CGL2010-18124) to J.C.A.; from the Spanish Ministry of Health (PI11-01532) to M.P.O.; and from the Spanish Ministry of Science and Innovation (BFU2009-11879/BFI), the Generalitat of Catalonia (2009SGR735), and the La MaratoTV3 Foundation to R.P. R.C. was supported by a Generalitat of Catalonia Predoctoral Fellowship. We thank David Argiles for excellent technical assistance. We thank Dr. Montserrat Rué for her support in statistical analyses. |
|
Materia(s):
|
-Longevity
-Plasma long-chain
-Metabolism |
|
Derechos:
|
cc-by-nc-nd (c) Jové Font, Mariona et al., 2013
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
|
|
Tipo de documento:
|
article
publishedVersion |
|
Editor:
|
Nature Publishing Group
|
|
Compartir:
|
|
