dc.contributor.author |
Rubinat, Esther |
dc.contributor.author |
Ortega, Emilio |
dc.contributor.author |
Traveset Maeso, Alicia |
dc.contributor.author |
Arcidiacono, Maria V. |
dc.contributor.author |
Alonso, Núria |
dc.contributor.author |
Betriu i Bars, M. Àngels |
dc.contributor.author |
Granado Casas, Minerva |
dc.contributor.author |
Hernández García, Marta |
dc.contributor.author |
Soldevila, Jordi |
dc.contributor.author |
Puig-Domingo, Manuel |
dc.contributor.author |
Jurjo Campo, Carmen |
dc.contributor.author |
Fernández i Giráldez, Elvira |
dc.contributor.author |
Mauricio Puente, Dídac |
dc.date |
2015-09-15T11:56:50Z |
dc.date |
2015-06-00 |
dc.date |
2015-09-15T11:56:50Z |
dc.date |
10000-01-01 |
dc.identifier |
0021-9150 |
dc.identifier |
http://hdl.handle.net/10459.1/48707 |
dc.identifier |
https://doi.org/10.1016/j.atherosclerosis.2015.05.024 |
dc.identifier.uri |
http://hdl.handle.net/10459.1/48707 |
dc.description |
Objective: We hypothesize that in type 1 diabetes vasa vasorum (VV) are affected by microangiopathic changes. For this purpose, we assessed the status of the VV signal in patients with type 1 diabetes. Methods: The VV signal at the arterial adventitia of the common carotid artery was evaluated by contrast-enhanced ultrasound imaging. The VV contrast agent signal was quantified in an plaque-free arterial segment as the ratio of the adventitial signal and that of the lumen of the artery. We studied 113 type 1 diabetic patients, 60 with and 53 without retinopathy and without known cardiovascular disease, and a group of 78 non-diabetic subjects free of cardiovascular risk factors. All study subjects underwent a clinical evaluation. Results: The mean ± standard deviation VV signal of healthy subjects was 0.562 ± 0.135. Type 1 diabetic patients showed a higher adventitial VV signal (0.723 ± 0.128) than non-diabetic subjects (P < 0.0001). After adjustment for cardiovascular risk confounders, this difference remained significant. No differences in VV signal, or common carotid intima-media thickness, between subjects with and without retinopathy were found. Conclusions: Type 1 diabetic patients, independently of their retinopathy status, show an increased angiogenesis of the VV of the common carotid artery compared with non-diabetic subjects. Diabetic microangiopathy, that according to our results would also affect the wall of the large arteries, could be a factor contributing to atherosclerosis in type 1 diabetes mellitus. |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
Elsevier |
dc.relation |
Reproducció del document publicat a: https://doi.org/10.1016/j.atherosclerosis.2015.05.024 |
dc.relation |
Atherosclerosis, 2015, vol. 241, num. 2, p. 334-338 |
dc.rights |
(c) Elsevier, 2015 |
dc.rights |
info:eu-repo/semantics/restrictedAccess |
dc.subject |
Malalties de la retina |
dc.subject |
Diabetis |
dc.subject |
Aterosclerosi |
dc.subject |
Retinal diseases |
dc.subject |
Diabetes |
dc.subject |
Atherosclerosis |
dc.title |
Microangiopathy of common carotid vasa vasorum in type 1 diabetes mellitus |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |