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Title:
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Microangiopathy of common carotid vasa vasorum in type 1 diabetes mellitus
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Author:
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Rubinat, Esther; Ortega, Emilio; Traveset Maeso, Alicia; Arcidiacono, Maria V.; Alonso, Núria; Betriu i Bars, M. Àngels; Granado Casas, Minerva; Hernández García, Marta; Soldevila, Jordi; Puig-Domingo, Manuel; Jurjo Campo, Carmen; Fernández i Giráldez, Elvira; Mauricio Puente, Dídac
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Notes:
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Objective: We hypothesize that in type 1 diabetes vasa vasorum (VV) are affected by microangiopathic changes. For this purpose, we assessed the status of the VV signal in patients with type 1 diabetes. Methods: The VV signal at the arterial adventitia of the common carotid artery was evaluated by contrast-enhanced ultrasound imaging. The VV contrast agent signal was quantified in an plaque-free arterial segment as the ratio of the adventitial signal and that of the lumen of the artery. We studied 113 type 1 diabetic patients, 60 with and 53 without retinopathy and without known cardiovascular disease, and a group of 78 non-diabetic subjects free of cardiovascular risk factors. All study subjects underwent a clinical evaluation. Results: The mean ± standard deviation VV signal of healthy subjects was 0.562 ± 0.135. Type 1 diabetic patients showed a higher adventitial VV signal (0.723 ± 0.128) than non-diabetic subjects (P < 0.0001). After adjustment for cardiovascular risk confounders, this difference remained significant. No differences in VV signal, or common carotid intima-media thickness, between subjects with and without retinopathy were found. Conclusions: Type 1 diabetic patients, independently of their retinopathy status, show an increased angiogenesis of the VV of the common carotid artery compared with non-diabetic subjects. Diabetic microangiopathy, that according to our results would also affect the wall of the large arteries, could be a factor contributing to atherosclerosis in type 1 diabetes mellitus. |
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Subject(s):
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-Malalties de la retina
-Diabetis
-Aterosclerosi
-Retinal diseases
-Diabetes
-Atherosclerosis |
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Rights:
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(c) Elsevier, 2015
info:eu-repo/semantics/restrictedAccess |
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Document type:
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Article
Article - Published version |
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Published by:
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Elsevier
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