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Mostrando ítems 1001-1020 de 431681
Prognostic model of long-term advanced stage (IIIB-IV) EGFR mutated non-small cell lung cancer (NSCLC) survivors using real-life data
Background There is a lack of useful diagnostic tools to identify EGFR mutated NSCLC patients with long-term survival. This study develops a prognostic model using real world data to assist clinicians to predict survival ...
Identification of the Immunological Changes Appearing in the CSF During the Early Immunosenescence Process Occurring in Multiple Sclerosis
Patients with multiple sclerosis (MS) suffer with age an early immunosenescence process, which influence the treatment response and increase the risk of infections. We explored whether lipid-specific oligoclonal IgM bands ...
Homologous Recombination Repair Gene Mutation Characterization by Liquid Biopsy: A Phase II Trial of Olaparib and Abiraterone in Metastatic Castrate-Resistant Prostate Cancer
Simple SummaryMutations in homologous recombination repair (HRR) genes are frequent in advanced prostate cancer and tumours harbouring these mutations have known sensitivity to PARP inhibitors, such as olaparib. In the ...
Epidemiology, treatment, and survival in small cell lung cancer in Spain: Data from the Thoracic Tumor Registry
Background Small-cell lung cancer (SCLC) is an aggressive disease with high metastatic potential and poor prognosis. Due to its low prevalence, epidemiological and clinical information of SCLC patients retrieved from lung ...
Influence of stroke infarct location on quality of life assessed in a multivariate lesion-symptom mapping study
Stroke has a deleterious impact on quality of life. However, it is less well known if stroke lesions in different brain regions are associated with reduced quality of life (QoL). We therefore investigated this association ...
Cerebellar Dysfunction in Adults with Prader Willi Syndrome
Severe hypotonia during infancy is a hallmark feature of Prader Willi syndrome (PWS). Despite its transient expression, moto development is delayed and deficiencies in motor coordination are present at older ages, with no ...
Metformin Is a Pyridoxal-5 '-phosphate (PLP)-Competitive Inhibitor of SHMT2
Simple Summary The mitochondrial enzyme serine hydroxymethyltransferase (SHMT2), which converts serine into glycine and generates 1C units for cell growth, is one of the most consistently overexpressed metabolic enzymes ...
Protein network analyses of pulmonary endothelial cells in chronic thromboembolic pulmonary hypertension
Chronic thromboembolic pulmonary hypertension (CTEPH) is a vascular disease characterized by the presence of organized thromboembolic material in pulmonary arteries leading to increased vascular resistance, heart failure ...
Lung, Breast and Colorectal Cancer Incidence by Socioeconomic Status in Spain: A Population-Based Multilevel Study
Simple Summary Despite political efforts across the world and Europe, social inequalities in cancer incidence are persistent. We studied the association between socioeconomic status (SES) and cancer incidence in nine ...
Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children
Both the innate and adaptive immune responses are deregulated in individuals with obesity and are key drivers of its associated metabolic alterations. Although the anti-inflammatory growth differentiation factor 15 (GDF-15) ...
Growth Hormone (GH) Treatment Decreases Plasma Kisspeptin Levels in GH-Deficient Adults with Prader-Willi Syndrome
Obesity and growth hormone (GH)-deficiency are consistent features of Prader-Willi syndrome (PWS). Centrally, kisspeptin is involved in regulating reproductive function and can stimulate hypothalamic hormones such as GH. ...
Multidimensional Evaluation of Awareness in Prader-Willi Syndrome
There are no studies about insight or awareness of illness in patients with Prader-Willi Syndrome (PWS). The objective of this study was to explore the level of awareness of the disorder, of the need for medication, and ...
Stabilisation of half MCM ring by Cdt1 during DNA insertion
Origin licensing ensures precise once per cell cycle replication in eukaryotic cells. The Origin Recognition Complex, Cdc6 and Cdt1 load Mcm2-7 helicase (MCM) into a double hexamer, bound around duplex DNA. The complex ...
Un passeig per s’Agaró : llegir les traces per lligar el litoral
El camí de ronda és un dels elements patrimonials més representatius de la Costa Brava, però avui es troba fragmentat per urbanitzacions, carreteres i infraestructures que n'interrompen la continuïtat. Aquest treball explora ...
Diseño de una práctica docente para el análisis del fenómeno de la inestabilidad
El presente documento aborda el estudio del fenómeno de inestabilidad en estructuras mediante el diseño y desarrollo de una práctica docente destinada a complementar las clases magistrales de la asignatura de Cálculo de ...
Rehabitar la planta baixa : estratègies per a la crisi d'habitatge a Barcelona : assaig al Poble-sec
Barcelona avui en dia, afronta una crisi d’habitatge que limita l’accés d’habitatge digne i assequible a una part important de la població. Davant la dificultat de generar nou sòl residencial, aquest treball planteja la ...
Modelling air traffic-related non-CO2 emissions and their health impacts on airport-adjacent communities
Aviation is known to play an important role in the emission of greenhouse gases, with substantial research backing figures such as the industry’s 2.5% share of global CO2 emissions in 2023 (IEA, 2023). While this focus is ...
Optimización para el cambio de material de una llanta de vehículo pesado
This work studies the potential of ultra-high-strength steel for the manufacturing of wheels in the heavy transport sector, aiming to find a competitive alternative that improves operational efficiency and reduces vehicle ...
Topos, Typo, Techne : reflexions i aproximacions a la lectura del vestigi
El present treball es presenta com un itinerari sensible entorn el concepte de vestigi. Els propòsits d’aquest treball, per tant, consisteixen en l’elaboració d’un quadern que aporta nocions sobre la lectura dels jaciments ...
L’Espai públic com a refugi climàtic : adaptació urbana de les places de Reus
L’augment de la freqüència, la intensitat i la durada de les onades de calor associades al canvi climàtic posa en crisi la capacitat de l’espai públic com a lloc habitable durant els mesos més calorosos. La majoria de les ...
