dc.contributor.author
Merino Montero, Susana
dc.contributor.author
Wilhelms, Markus
dc.contributor.author
Tomàs Magaña, Juan
dc.date.issued
2015-01-12T15:34:44Z
dc.date.issued
2015-01-12T15:34:44Z
dc.date.issued
2014-10-28
dc.date.issued
2015-01-12T15:34:44Z
dc.identifier
https://hdl.handle.net/2445/61173
dc.description.abstract
Polar flagellin proteins from Aeromonas hydrophila strain AH-3 (serotype O34) were found to be O-glycosylated with a heterogeneous heptasaccharide glycan. Two mutants with altered (light and strong) polar flagella glycosylation still able to produce flagella were previously obtained, as well as mutants lacking the O34-antigen lipopolysaccharide (LPS) but with unaltered polar flagella glycosylation. We compared these mutants, altogether with the wild type strain, in different studies to conclude that polar flagella glycosylation is extremely important for A. hydrophila adhesion to Hep-2 cells and biofilm formation. Furthermore, the polar flagella glycosylation is an important factor for the immune stimulation of IL-8 production via toll receptor 5 (TLR5).
dc.format
application/pdf
dc.format
application/pdf
dc.relation
Reproducció del document publicat a: http://dx.doi.org/10.3390/ijms151221935
dc.relation
International Journal of Molecular Sciences, 2014, vol. 15, p. 21935-21946
dc.relation
http://dx.doi.org/10.3390/ijms151221935
dc.rights
cc-by (c) Merino Montero, Susana et al., 2014
dc.rights
http://creativecommons.org/licenses/by/3.0/es
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Genètica, Microbiologia i Estadística)
dc.subject
Regulació genètica
dc.subject
Genetic regulation
dc.title
Role of Aeromonas hydrophila flagella glycosylation in adhesion to Hep-2 cells, biofilm formation and immune stimulation.
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
