Preparation of alpha-labeled aldehydes by base-catalyzed exchange reactions

Publication date

2013-12-20T11:19:18Z

2019-11-01T06:10:12Z

2010

2013-12-20T10:36:31Z

Abstract

A simple, efficient protocol for the preparation of α-labeled aldehydes based on H/D exchange catalyzed by 4-(N,N-dimethylamino)pyridine or Et3N is described. High chemical yields and ratios of isotope incorporation were obtained even when small amounts (1 mmol) of aldehyde were used.

Document Type

Article


Submitted version

Language

English

Publisher

John Wiley & Sons

Related items

Versió preprint del document publicat a: http://dx.doi.org/10.1002/jlcr.1759

Journal of Labelled Compounds and Radiopharmaceuticals, 2010, vol. 53, num. 8, p. 556-558

http://dx.doi.org/10.1002/jlcr.1759

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Rights

(c) John Wiley & Sons, 2010