dc.contributor.author
Rodríguez-Frías, Francisco
dc.contributor.author
Tabernero, David
dc.contributor.author
Quer, Josep
dc.contributor.author
Esteban, Juan I.
dc.contributor.author
Ortega, Israel
dc.contributor.author
Domingo, Esteban
dc.contributor.author
Cubero, Maria
dc.contributor.author
Camos, Sílvia
dc.contributor.author
Ferrer Costa, Carles
dc.contributor.author
Sànchez, Àlex (Sànchez Pla)
dc.contributor.author
Jardí, Rosendo
dc.contributor.author
Schaper, Melanie
dc.contributor.author
Homs, Maria
dc.contributor.author
García Cehic, Damir
dc.contributor.author
Guardia, Jaume
dc.contributor.author
Esteban, Rafael
dc.contributor.author
Buti, Maria
dc.date.issued
2013-05-07T17:43:09Z
dc.date.issued
2013-05-07T17:43:09Z
dc.date.issued
2012-05-30
dc.date.issued
2013-05-07T17:43:09Z
dc.identifier
https://hdl.handle.net/2445/43202
dc.description.abstract
Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping surface coding region. In this study, the variability of an overlapping polymerase-surface region, critical for NA resistance, is investigated before treatment and under antiviral therapy, with assessment of NA-resistant amino acid changes simultaneously occurring in the same genome (linkage analysis) and their influence on the surface coding region.
dc.format
application/pdf
dc.format
application/pdf
dc.publisher
Public Library of Science (PLoS)
dc.relation
Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0037874
dc.relation
PLoS One, 2012, vol. 7, num. 5, p. e37874
dc.relation
http://dx.doi.org/10.1371/journal.pone.0037874
dc.rights
cc-by (c) Rodriguez Frías, F. et al., 2012
dc.rights
http://creativecommons.org/licenses/by/3.0/es
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Genètica, Microbiologia i Estadística)
dc.subject
Medicaments antivírics
dc.subject
Expressió gènica
dc.subject
Antiviral agents
dc.subject
Gene expression
dc.title
Ultra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
