dc.contributor.author
Rodriguez, Jessica
dc.contributor.author
Battistini, Federica
dc.contributor.author
Learte-Aymamí, Soraya
dc.contributor.author
Orozco López, Modesto
dc.contributor.author
Mascareñas, José L.
dc.date.issued
2026-02-25T13:20:47Z
dc.date.issued
2026-02-25T13:20:47Z
dc.date.issued
2026-02-25T13:20:54Z
dc.identifier
https://hdl.handle.net/2445/227420
dc.description.abstract
We report the modelling of the DNA complex of an artificial miniprotein composed of two zinc finger modules and an AT-hook linking peptide. The computational study provides for the first time a structural view of these types of complexes, dissecting interactions that are key to modulate their stability. The relevance of these interactions was validated experimentally. These results confirm the potential of this type of computational approach for studying peptide–DNA complexes and suggest that they could be very useful for the rational design of non-natural, DNA binding miniproteins.
dc.format
application/pdf
dc.publisher
Royal Society of Chemistry
dc.relation
Reproducció del document publicat a: https://doi.org/10.1039/d3cb00053b
dc.relation
RSC Chemical Biology, 2023, vol. 4, p. 486-493
dc.relation
https://doi.org/10.1039/d3cb00053b
dc.rights
cc-by-nc (c) J Rodriguez et al., 2023
dc.rights
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Biologia molecular
dc.subject
Molecular biology
dc.title
Molecular dynamics modelling of the interaction of a synthetic zinc-finger miniprotein with DNA
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
