dc.contributor.author
Palazón Barandela, Javier
dc.contributor.author
Navarro-Ocaña, Arturo
dc.contributor.author
Hernández-Vázquez, Liliana
dc.contributor.author
Mirjalili, Mohammad Hossein
dc.date.issued
2011-11-18T11:50:56Z
dc.date.issued
2011-11-18T11:50:56Z
dc.date.issued
2008-08-18
dc.identifier
https://hdl.handle.net/2445/20789
dc.description.abstract
Scopolamine is an alkaloid widely used in medicine for its anticholinergic activity. The aim of this review is to show that metabolic engineering techniques constitute a suitable tool to improve the production of tropane alkaloids, focusing in particular on scopolamine. We present an overview of results obtained by various research groups, including our own, who have studied the overexpression of genes involved in the biosynthesis of scopolamine in different plant species that produce tropane alkaloids. Experiments carried out to improve production in hairy root cultures will also be described, as well as those attempting to biotransform hyoscyamine into scopolamine in roots and transgenic tobacco cells.
dc.format
application/pdf
dc.publisher
MDPI Publishing
dc.relation
Reproducció del document publicat a: http://dx.doi.org/10.3390/molecules13081722
dc.relation
Molecules 2008, 13(8), 1722-1742
dc.relation
http://dx.doi.org/10.3390/molecules13081722
dc.rights
cc-by, (c) Palazón et al., 2008
dc.rights
http://creativecommons.org/licenses/by/3.0/es
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)
dc.subject
Enginyeria bioquímica
dc.subject
Biochemical engineering
dc.title
Application of metabolic engineering to the production of scopolamine
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
