dc.contributor.author
Rodríguez Urgellés, Ened
dc.contributor.author
Casas Torremocha, Diana
dc.contributor.author
Sancho Balsells, Anna
dc.contributor.author
Ballasch, Iván
dc.contributor.author
García-García, Esther
dc.contributor.author
Miquel Rio, Lluís
dc.contributor.author
Manasanch, Arnau
dc.contributor.author
Del Castillo, Ignacio
dc.contributor.author
Chen, Wanqi
dc.contributor.author
Pupak, Anika
dc.contributor.author
Brito, Verónica
dc.contributor.author
Tornero, Daniel
dc.contributor.author
Rodríguez Allué, Manuel José
dc.contributor.author
Bortolozzi Biasoni, Analía
dc.contributor.author
Sánchez-Vives, María Victoria
dc.contributor.author
Giralt Torroella, Albert
dc.contributor.author
Alberch i Vié, Jordi, 1959-
dc.date.issued
2024-02-15T16:27:13Z
dc.date.issued
2023-11-21
dc.date.issued
2024-02-15T16:27:13Z
dc.identifier
https://hdl.handle.net/2445/207639
dc.identifier
10.1007/s00018-023-05015-z
dc.description.abstract
Here, we demonstrate in a HD mouse model a clear and early thalamo-striatal aberrant connectivity associated with a reduction of thalamic Foxp2 levels. Recovering thalamic Foxp2 levels in the mouse rescued motor coordination and sensory skills concomitant with an amelioration of neuropathological features and with a repair of the structural and functional connectivity through a restoration of neurotransmitter release. In addition, reduction of thalamic Foxp2 levels in wild type mice induced HD-like phenotypes.
dc.format
application/pdf
dc.publisher
Springer Verlag
dc.relation
Reproducció del document publicat a: https://doi.org/10.1007/s00018-023-05015-z
dc.relation
Cellular and Molecular Life Sciences, 2023, vol. 80, num.12
dc.relation
https://doi.org/10.1007/s00018-023-05015-z
dc.rights
cc by (c) Rodríguez Urgellés, Ened et al., 2023
dc.rights
http://creativecommons.org/licenses/by/3.0/es/
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Biomedicina)
dc.subject
Corea de Huntington
dc.subject
Ganglis basals
dc.subject
Neurones sensorials
dc.subject
Electrofisiologia
dc.subject
Huntington's chorea
dc.subject
Sensory neurons
dc.subject
Electrophysiology
dc.title
Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
