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Clinical Implications of Genomic Profile in Waldenström Macroglobulinemia

Autor/a

Moreno, D. F.

Fernández de Larrea Rodríguez, Carlos José

Fecha de publicación

2024-02-06T11:44:08Z

2024-06-27T05:10:13Z

2023-08-01

2024-02-06T10:14:44Z

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Resumen

With the increasing availability of sequencing techniques and new polymerase chain reaction-based methods, data regarding the genomic profile of Waldenström macroglobulinemia (WM) are being continuously analyzed and reproduced. MYD88 and CXCR4 mutations are highly prevalent in all the stages of WM, including the early IgM monoclonal gammopathy of undetermined significance or a more advanced stage, such as smoldering WM. Thus, there is a need to define genotypes before starting either standard treatment regimens or clinical trials. Here, we review the genomic profile of WM and its clinical implications while focusing on recent advances.Copyright © 2023 Elsevier Inc. All rights reserved.

Tipo de documento

Artículo

Versión publicada

Lengua

Inglés

Materias y palabras clave

Limfomes; Mutació (Biologia); Lymphomas; Mutation (Biology)

Publicado por

Elsevier

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Reproducció del document publicat a: https://doi.org/10.1016/j.hoc.2023.04.002

Hematology-Oncology Clinics Of North America, 2023, vol. 37, num. 4, p. 659-670

https://doi.org/10.1016/j.hoc.2023.04.002

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Derechos

cc by-nc-nd (c) Elsevier, 2024

http://creativecommons.org/licenses/by-nc-nd/3.0/es/

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IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer [3164]

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