dc.contributor.author
Panagopoulou, Maria
dc.contributor.author
Esteller, Manel
dc.contributor.author
Chatzaki, Ekaterini
dc.date.issued
2022-04-01T17:46:20Z
dc.date.issued
2022-04-01T17:46:20Z
dc.date.issued
2021-02-10
dc.date.issued
2022-04-01T17:46:21Z
dc.identifier
https://hdl.handle.net/2445/184630
dc.description.abstract
Breast cancer (BC) is a leading cause of death between women. Mortality is significantly raised due to drug resistance and metastasis, while personalized treatment options are obstructed by the limitations of conventional biopsy follow-up. Lately, research is focusing on circulating biomarkers as minimally invasive choices for diagnosis, prognosis and treatment monitoring. Circulating cell-free DNA (ccfDNA) is a promising liquid biopsy biomaterial of great potential as it is thought to mirror the tumor's lifespan; however, its clinical exploitation is burdened mainly by gaps in knowledge of its biology and specific characteristics. The current review aims to gather latest findings about the nature of ccfDNA and its multiple molecular and biological characteristics in breast cancer, covering basic and translational research and giving insights about its validity in a clinical setting.
dc.format
application/pdf
dc.relation
Reproducció del document publicat a: https://doi.org/10.3390/cancers13040728
dc.relation
Cancers, 2021, vol. 13, num. 4, p. 728
dc.relation
https://doi.org/10.3390/cancers13040728
dc.rights
cc-by (c) Panagopoulou, Maria et al., 2021
dc.rights
https://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Ciències Fisiològiques)
dc.subject
Càncer de mama
dc.subject
Pronòstic mèdic
dc.subject
Marcadors bioquímics
dc.subject
Biochemical markers
dc.title
Circulating cell-free DNA in breast cancer: searching for hidden information towards precision medicine
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
